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Chromosome Analysis, Leukemia/Lymphoma With Reflex to Chromosome Microarray (CMA)
- Hematologic Disorders, Chromosome Analysis
- Philadelphia Chromosome
Short- and (in some cases) long-term β-mitogen culturing of specimens, chromosome preparation, and analysis of 20 metaphases; multiple karyotypes prepared, including all abnormal clones; reflex to SNP microarray (Reveal®) if chromosome analysis is normal
Karyotyping, physical localization of copy number changes, and mapping of breakpoints involved in translocations for the diagnosis/prognosis of leukemia/lymphoma subgroups.
In studies of myeloid malignancy (eg, MDS in blood), availability of immature blasts, excessive amounts of sodium heparin, or use of lithium heparin, or EDTA will inhibit growth of cell culture.
Short-term cell culture; synchronization; chromosome harvest; G-banding; analysis (20 metaphases) and karyotyping; long-term β-mitogen cultures in some β-cell leukemias
Bone marrow, blood (>4% blasts required; see Collection), lymph node, spleen, bone core, or effusion
2 mL bone marrow, 3 mL peripheral blood, or 0.5 to 1 cm³ tissue
The requirement of >4% blasts for blood does not apply to cases of CLL, hairy cell leukemia, and some cases of small cell lymphocytic leukemia (SCLL) or lymphoma, which can be β-mitogen stimulated. Submit bone marrow or peripheral blood at room temperature using the Leukemia/Lymphoma Specimen Transport Kit (supplied by LabCorp). Submit lymph node, spleen, or bone core at room temperature using Lymph Node Transport Kit (supplied by LabCorp). Effusions may be sent in the same sterile containers. Specimens should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on the test request form.
Maintain specimen at room temperature.
Causes for Rejection
Hemolysis; gross contamination; nonneoplastic cells; clotted specimen; frozen specimen; fixed specimen; use of improper or too much anticoagulant
Indicate the tentative diagnosis on the test request form. This is necessary for proper culturing and result interpretation. Please direct any questions regarding this test to customer service at 800-345-4363.