Celiac Antibodies tTG IgA, EMA IgA, Total IgA With Reflex to tTG IgG

CPT: 82784; 83516; 86255. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Details

Synonyms

  • Endomysial Antibodies
  • Tissue Transglutaminase (tTG) Antibodies

Test Includes

Endomysial antibody, IgA; tissue transglutaminase (tTG), IgA; total IgA; reflex to tissue transglutaminase (tTG), IgG

Use

Aid in the diagnosis of gluten-sensitive enteropathies

Methodology

Enzyme immunoassay (EIA); indirect immunofluorescence

Additional Information

Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as 1% of the population in the US. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, etc. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time.

Specimen Requirements

Specimen

Serum

Volume

3 mL

Minimum Volume

1 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

Clinical Information

Special Instructions

Reflex testing for tissue transglutaminase (tTG) IgG antibodies is performed if total IgA is decreased.

References

Baigi F, Pezzimenti D, Campanella J, et al. Endomysial and tissue transglutaminase antibodies in coeliac sera: A comparison not influenced by previous serological testing. Scand J Gastroenterol. 2001 Sep; 36(9):955-958. 11521986
Bürgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug; 66(8):941-947. 1819255
Calabuig M, Torregosa R, Polo P, et al. Serological markers and celiac disease: A new diagnostic approach? Pediatr Gastroenterol Nutr. 1990 May; 10(4):435-442. 2193137
Green PH, Jabri B. Coeliac disease. Lancet. 2003 Aug 2; 362(9381):383-391. 12907013
National Institutes of Health Consensus Development Conference Statement on Celiac Disease, 2004.
Pruessner HT. Detecting celiac disease in your patients. Am Fam Physician. 1998 Mar 1; 57(5):1023-1034, 1039-1041. 9518950

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
165142 Celiac Disease Panel 164997 Endomysial Antibody IgA 10362-2
165142 Celiac Disease Panel 164643 t-Transglutaminase (tTG) IgA U/mL 31017-7
165142 Celiac Disease Panel 001784 Immunoglobulin A, Qn, Serum mg/dL 2458-8
Reflex Table for Immunoglobulin A, Qn, Serum
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 164988 t-Transglutaminase (tTG) IgG 164989 t-Transglutaminase (tTG) IgG U/mL 32998-7

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