Celiac Antibodies Profile tTG IgA, tTG IgG, DGP IgA, DGP IgG, EMA IgA, and Total IgA

CPT: 82784; 83516(x4); 86255
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Test Details

Synonyms

  • Deamidated Gliadin
  • Endomysial IgA Antibodies

Test Includes

Deamidated gliadin antibodies; endomysial antibodies; tissue transglutaminase (tTG) antibodies; total IgA

Use

Aid in the diagnosis of gluten-sensitive enteropathies

Methodology

Enzyme immunoassay (EIA); indirect immunofluorescence

Additional Information

Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as 1% of the population in the US. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, etc. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time.

Specimen Requirements

Specimen

Serum

Volume

3 mL

Minimum Volume

1.75 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

Clinical Information

References

Agardh D. Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol. 2007 Nov; 5(11):1276-1281. 17683995
Baigi F, Pezzimenti D, Campanella J, et al. Endomysial and tissue transglutaminase antibodies in coeliac sera: A comparison not influenced by previous serological testing. Scand J Gastroenterol. 2001 Sep; 36(9):955-958. 11521986
Bürgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug; 66(8):941-947. 1819255
Calabuig M, Torregosa R, Polo P, et al. Serological markers and celiac disease: A new diagnostic approach? Pediatr Gastroenterol Nutr. 1990 May; 10(4):435-442. 2193137
Green PH, Jabri B. Coeliac disease. Lancet. 2003 Aug 2; 362(9381):383-391.12907013
Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005 Jan; 40(1):1-19. 15625418
Kaukinen K, Collin P, Laurila K, Kaartinen T, Partanen J, Mäki M. Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit. Scand J Gastroenterol. 2007 Dec; 42(12):1428-1433. 17852878
National Institutes of Health Consensus Development Conference Statement on Celiac Disease, 2004.
Pruessner HT. Detecting celiac disease in your patients. Am Fam Physician. 1998 Mar 1; 57(5):1023-1034, 1039-1041. 9518950

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
165126 Celiac Disease Comprehensive 161652 Deamidated Gliadin Abs, IgA units 58709-7
165126 Celiac Disease Comprehensive 161693 Deamidated Gliadin Abs, IgG units 58710-5
165126 Celiac Disease Comprehensive 164643 t-Transglutaminase (tTG) IgA U/mL 31017-7
165126 Celiac Disease Comprehensive 164989 t-Transglutaminase (tTG) IgG U/mL 32998-7
165126 Celiac Disease Comprehensive 164997 Endomysial Antibody IgA 10362-2
165126 Celiac Disease Comprehensive 001784 Immunoglobulin A, Qn, Serum mg/dL 2458-8

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