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Bone Marrow Aspiration and Biopsy
- Bone Marrow Aspirate
- Iron Stain, Bone Marrow
H and E stain; iron stain; Wright stain
Evaluate bone marrow morphology, erythropoiesis, myelopoiesis, myeloid:erythroid ratio, megakaryocytes, cellularity, and marrow iron stores; evaluate etiology of abnormalities of production of RBC, WBC, or platelets; establish the presence of various primary or secondary malignancies: myeloma, carcinoma, lymphoproliferative diseases, or myeloproliferative diseases; evaluate respiratory therapy of hematologic disorders
Marrow culture can make valuable contribution to study of fever of undetermined origin and possible systemic infection, in particular, histoplasmosis and tuberculosis.
Bone marrow aspirate clot and/or biopsy, bone marrow aspirate smears, and peripheral blood smears
2 to 5 mL, at least 1 cm core of bone marrow (complete specimen), bilateral if for staging of lymphoma
Smeared slides are prepared and labeled at the bedside by a laboratory technologist. Biopsy and clot are placed in fixative by technologist. Bone marrow smears for enzyme histochemistry must be fixed immediately in 10% neutral buffered formalin, absolute methyl alcohol, or 40% formalin vapor. Fixative container must be labeled with patient's full name, room number, date, and time and the fixative employed.
Causes for Rejection
No marrow obtained
Must include clinical/laboratory information, clinical hematological diagnosis, and a recent CBC or peripheral blood in EDTA.