Bone Marrow Aspiration and Biopsy

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Test Details

Synonyms

  • Bone Marrow Aspirate
  • Iron Stain, Bone Marrow

Test Includes

H and E stain; iron stain; Wright stain

Use

Evaluate bone marrow morphology, erythropoiesis, myelopoiesis, myeloid:erythroid ratio, megakaryocytes, cellularity, and marrow iron stores; evaluate etiology of abnormalities of production of RBC, WBC, or platelets; establish the presence of various primary or secondary malignancies: myeloma, carcinoma, lymphoproliferative diseases, or myeloproliferative diseases; evaluate respiratory therapy of hematologic disorders

Additional Information

Marrow culture can make valuable contribution to study of fever of undetermined origin and possible systemic infection, in particular, histoplasmosis and tuberculosis.

Specimen Requirements

Specimen

Bone marrow aspirate clot and/or biopsy, bone marrow aspirate smears, and peripheral blood smears

Volume

2 to 5 mL, at least 1 cm core of bone marrow (complete specimen), bilateral if for staging of lymphoma

Collection

Smeared slides are prepared and labeled at the bedside by a laboratory technologist. Biopsy and clot are placed in fixative by technologist. Bone marrow smears for enzyme histochemistry must be fixed immediately in 10% neutral buffered formalin, absolute methyl alcohol, or 40% formalin vapor. Fixative container must be labeled with patient's full name, room number, date, and time and the fixative employed.

Causes for Rejection

No marrow obtained

Clinical Information

Special Instructions

Must include clinical/laboratory information, clinical hematological diagnosis, and a recent CBC or peripheral blood in EDTA.

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf