BCR-ABL1 Oncology, FISH

CPT: 88271(x2); 88275
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Test Details

Synonyms

  • ALL FISH
  • CML FISH

Use

Confirmation/identification of leukemia/lymphoma-related alterations; leukemia/lymphoma monitoring of residual disease.

Methodology

Fluorescence in situ hybridization (FISH)

Specimen Requirements

Specimen

Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF).

Volume

Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow

Container

Green-top (heparin) tube, pediatric Vacutainer® (optimal), or lavender-top (EDTA) tube

Collection

Transport to the testing lab at room temperature; LabCorp transport kit. Do not allow sample to overheat or freeze.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides/paraffin blocks; decalcified bone cores; frozen specimen

Clinical Information

Special Instructions

Pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest should be included with the specimen. Please provide targeted FISH probe and diagnosis.

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf