Bartonella Antibody Profile

CPT: 86611(x4)
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Test Details

Synonyms

  • Rochalimaea
  • Bacillary Angiomatosis (BA)
  • Cat Scratch Disease Antibody

Test Includes

Bartonella henselae, IgG; Bartonella henselae, IgM; Bartonella quintana, IgG; Bartonella quintana, IgM

Use

Bartonella (formerly Rochalimaea) henselae has become firmly established as the primary etiologic agent for cat scratch disease (CSD). Bartonella quintana, known for some time as a cause of trench fever, is also associated with CSD and bacillary angiomatosis (BA). Both diseases frequently affect immunocompromised patients, particularly those infected with HIV-1. Although CSD is generally a self-limiting disease, it can be life-threatening.

Limitations

There is some cross-reactivity between the IgG classes of B henselae and B quintana.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary.

Methodology

Indirect fluorescent antibody (IFA)

Specimen Requirements

Specimen

Serum

Volume

2 mL

Minimum Volume

1 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Refrigerate.

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

Clinical Information

References

Anderson BE, Neuman MA. Bartonella spp as emerging human pathogens. Clin Microbiol Rev. 1997 Apr; 10(2):203-219. 9105751
Chomel BB, Abbott RC, Kasten RW, et al. Bartonella henselae prevalence in domestic cats in California: Risk factors and association between bacteremia and antibody titers. J Clin Microbiol. 1995 Sep; 33(9):2445-2450. 7494043
Regnery RL, Anderson BE, Clarridge JE 3rd, Rodríguez-Barradas MC, Jones DC, Carr JH. Characterization of a novel Rochalimaea species, R. henselae sp. nov., isolated from blood of a febrile, human immunodeficiency virus-positive patient. J Clin Microbiol. 1992 Feb; 30(2):265-274. 1371515
Regnery R, Tappero J. Unraveling mysteries associated with cat-scratch disease, bacillary angiomatosis, and related syndromes. Emerg Infect Dis. 1995 Jan-Mar; 1(1):16-21. 8903149
Sander A, Posselt M, Oberle K, Bredt W. Seroprevalence of antibodies to Bartonella henselae in patients with cat scratch disease and in healthy controls: Evaluation and comparison of two commercial serological tests. Clin Diagn Lab Immunol. 1998 Jul; 5(4):486-490. 9665953
Welch DF, Pickett DA, Slater LN, Steigerwalt AG, Brenner DJ. Rochalimaea sp. nov., a cause of septicemia, bacillary angiomatosis, and parenchymal bacillary peliosis. J Clin Microbiol. 1992 Feb; 30(2):275-280. 1537892

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163162 Bartonella Antibody Panel 163163 B. henselae IgG titer 6954-2
163162 Bartonella Antibody Panel 163164 B. henselae IgM titer 6955-9
163162 Bartonella Antibody Panel 163165 B. quintana IgG titer 44827-4
163162 Bartonella Antibody Panel 163168 B. quintana IgM titer 44825-8

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf