Apolipoprotein B

CPT: 82172
Updated on 2/12/2019
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Test Details

Synonyms

  • Beta Apolipoprotein

Use

LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis and its quantitation useful in the evaluation of patients at risk for or having coronary atherosclerosis (CAD). High levels indicate increased risk for CAD.

LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis and its quantitation useful in the evaluation of patients at risk for or having coronary atherosclerosis (CAD).1 High levels indicate increased risk for CAD.

LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis and its quantitation useful in the evaluation of patients at risk for or having coronary atherosclerosis (CAD). High levels indicate increased risk for CAD.

Methodology

Immunologic

Reference Interval

Apolipoprotein B (mg/dL)

Desirable

Borderline High

High

Very High

<90

90 – 99

100 – 120

>120

ASCVD Risk Category

Therapeutic Target APO B (mg/dL)

Very High Risk

<80 (if extreme risk <70)

High Risk

<90

Moderate Risk

<90

<p>See table.

Age

Male (mg/dL)

Female (mg/dL)

0 to 14 d

9−67

9−67

15 d to 11 m

19−123

19−123

1 to 5 y

41−93

41−93

>5 y

52−135

54−133

<table>

Apolipoprotein B (mg/dL)

Desirable

Borderline High

High

Very High

<90

90 – 99

100 – 120

>120

ASCVD Risk Category

Therapeutic Target APO B (mg/dL)

Very High Risk

<80 (if extreme risk <70)

High Risk

<90

Moderate Risk

<90

Specimen Requirements

Specimen

Serum (preferred) or plasma

Volume

2 mL

Container

Red-top tube, gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube

Patient Preparation

Patient must be fasting 12 to 14 hours.

Collection

Separate serum or plasma from cells. Transfer specimen to a plastic transport tube.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Specimen from nonfasting patient

Clinical Information

References

Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory reference intervals: A CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012 May; 58(5):854-868.22371482
Contois JH, McConnell JP, Sethi AA, et al. Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem. 2009 Mar;55(3):407-419.19168552
Jacobson TA, Ito MK, Maki KC, et al. National lipid association recommendations for patient-centered management of dyslipidemia: part 1–full report. J Clin Lipidol. 2015 Mar-Apr;9(2):129-169.25911072
Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory reference intervals: A CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012 May; 58(5):854-868. 22371482
Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory reference intervals: A CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012 May; 58(5):854-868.22371482
Contois JH, McConnell JP, Sethi AA, et al. Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem. 2009 Mar;55(3):407-419.19168552
Jacobson TA, Ito MK, Maki KC, et al. National lipid association recommendations for patient-centered management of dyslipidemia: part 1–full report. J Clin Lipidol. 2015 Mar-Apr;9(2):129-169.25911072

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
167015 Apolipoprotein B 1884-6 167015 Apolipoprotein B mg/dL 1884-6

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