Antiscleroderma − 70 Antibodies

CPT: 86235
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Synonyms

  • Anti-Scl 70

Test Includes

Semiquantitative result of IgG class antibodies


Expected Turnaround Time

1 - 3 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Hemolysis; icterus; lipemia; gross bacterial contamination


Test Details


Use

Differential diagnosis of scleroderma (progressive systemic sclerosis)


Methodology

Multiplex flow immunoassay


Reference Interval

0.0−0.9 AI


Additional Information

Scl-70 antibody is seen in 20% of patients with scleroderma, and in some patients with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia). These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
018705 Antiscleroderma-70 Antibodies 27416-7 018707 Antiscleroderma-70 Antibodies AI 27416-7

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