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Antidiuretic Hormone (ADH) Profile
- Arginine Vasopressin
Aid in the diagnosis of urine concentration disorders, especially diabetes insipidus, syndrome of inappropriate ADH (SIADH), psychogenic water intoxication, and syndromes of ectopic ADH production
Results for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.
ADH: radioimmunoassay (RIA); osmolality: freezing point depression
• ADH: 0.0−4.7 pg/mL
− Neonates: May be as low as 266 mOsmol/kg
− 0 to 60 years: 275−295 mOsmol/kg
− >60 years: 280−301 mOsmol/kg
ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause increase in permeability to water and urea. ADH release is triggered by a number of both osmotic and nonosmotic stimuli. Measurement of ADH is useful in separating central diabetes insipidus, which is marked by polydipsia and polyuria and is caused by inadequate ADH production from nephrogenic diabetes insipidus caused by the inability of renal tubules to respond to ADH. In SIADH, release of ADH is disproportionate to a low serum osmolality. SIADH results due to a number of conditions such as pulmonary disease, head trauma, and cancer.
Serum, refrigerated and plasma, frozen
1 mL serum and 2 mL plasma
0.5 mL serum and 1 mL plasma (Note: This volume does not allow for repeat testing.)
Draw serum and plasma samples and separate from cells using a refrigerated centrifuge. Transfer separated samples into clearly labeled “plasma” and “serum” plastic transport tubes. Freeze plasma immediately and refrigerate serum. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Causes for Rejection
Recently administered isotopes; serum specimen not received; plasma specimen not received frozen
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|046557||Antidiuretic Hormone Profile||010449||ADH||pg/mL||3126-0|
|046557||Antidiuretic Hormone Profile||002071||Osmolality||mOsmol/kg||2692-2|