Antidiuretic Hormone (ADH) Profile

CPT: 83930; 84588
Updated on 1/24/2018
Print Share

Test Details

Synonyms

  • ADH
  • Arginine Vasopressin
  • AVP
  • Vasopressin

Test Includes

ADH; osmolality

Use

Aid in the diagnosis of urine concentration disorders, especially diabetes insipidus, syndrome of inappropriate ADH (SIADH), psychogenic water intoxication, and syndromes of ectopic ADH production

Limitations

Results for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

Methodology

ADH: radioimmunoassay (RIA); osmolality: freezing point depression

Reference Interval

• ADH: 0.0−4.7 pg/mL

• Osmolality:

− Neonates: May be as low as 266 mOsmol/kg

− 0 to 60 years: 275−295 mOsmol/kg

− >60 years: 280−301 mOsmol/kg

Additional Information

ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause increase in permeability to water and urea. ADH release is triggered by a number of both osmotic and nonosmotic stimuli. Measurement of ADH is useful in separating central diabetes insipidus, which is marked by polydipsia and polyuria and is caused by inadequate ADH production from nephrogenic diabetes insipidus caused by the inability of renal tubules to respond to ADH. In SIADH, release of ADH is disproportionate to a low serum osmolality. SIADH results due to a number of conditions such as pulmonary disease, head trauma, and cancer.

Specimen Requirements

Specimen

Serum, refrigerated and plasma, frozen

Volume

1 mL serum and 2 mL plasma

Minimum Volume

0.5 mL serum and 1 mL plasma (Note: This volume does not allow for repeat testing.)

Container

Gel-barrier tube and lavender-top (EDTA) tube

Patient Preparation

No isotopes administered 24 hours prior to venipuncture

Collection

Draw serum and plasma samples and separate from cells using a refrigerated centrifuge. Transfer separated samples into clearly labeled “plasma” and “serum” plastic transport tubes. Freeze plasma immediately and refrigerate serum. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze plasma immediately. Refrigerate serum.

Causes for Rejection

Recently administered isotopes; serum specimen not received; plasma specimen not received frozen

Clinical Information

References

Cowley AW Jr, Cushman WC, Quillen EW Jr, et al. Vasopressin elevation in essential hypertension and increased responsiveness to sodium intake. Hypertension. 1981; 3(3 Pt 2):I93-100. 7262983
Malvin RL. Possible role of the renin-angiotensin system in the regulation of antidiuretic hormone secretion. Fed Proc. 1971; 30(4):1383-1386. 4326738
Pullan PT, Clappison BH, Johnston CI. Plasma vasopressin and human neurophysins and physiological and pathological states associated with changes in vasopressin secretion. J Clin Endocrinol Metab. 1979; 49(4):580-587. 479348

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
046557 Antidiuretic Hormone Profile 010449 ADH pg/mL 3126-0
046557 Antidiuretic Hormone Profile 002071 Osmolality mOsmol/kg 2692-2

For Providers

Please login to order a test.

 

© 2018  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf