Amino Acid Profile, Quantitative, Plasma

CPT: 82139
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Test Details

Use

Diagnosis and monitoring of inherited aminoacidurias, organic acidurias, and urea cycle defects. May be used as a follow-up confirmatory test to some abnormal newborn screen results.

Limitations

False-negative results can occur, especially when a patient is affected with a mild or intermittent variant of a disorder or when clinical condition or dietary treatment causes secondary changes to the profile. Results of amino acid profiling should be interpreted in the context of clinical presentation, as well as other laboratory tests.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

See Plasma Amino Acid Reference Intervals in the Test Resources pages online.

Specimen Requirements

Specimen

Plasma, frozen

Volume

0.5 mL

Minimum Volume

0.25 mL

Container

Green-top (heparin) tube

Collection

Separate plasma from cells. Transfer specimen to plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Centrifuge, remove plasma from cells, and freeze immediately.

Stability Requirements

Temperature

Period

Room temperature

Unstable

Refrigerated

Unstable

Frozen

14 days

Causes for Rejection

Gross hemolysis; room temperature or thawed specimen; specimens collected in yellow-top (ACD) tubes

Clinical Information

References

Bremer HJ, Duran M, Kamerling JP, et al. Disturbances of Amino Acid Metabolism: Clinical Chemistry and Diagnosis. Baltimore, Md: Urban and Schwarzenberg; 1981.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
700068 Amino Acid Profile, Qn, Plasma 700007 Taurine umol/L 20657-3
700068 Amino Acid Profile, Qn, Plasma 700008 Aspartate umol/L 20639-1
700068 Amino Acid Profile, Qn, Plasma 700009 Hydroxyproline umol/L 20647-4
700068 Amino Acid Profile, Qn, Plasma 700010 Threonine umol/L 20658-1
700068 Amino Acid Profile, Qn, Plasma 700011 Serine umol/L 20656-5
700068 Amino Acid Profile, Qn, Plasma 700012 Asparagine umol/L 20638-3
700068 Amino Acid Profile, Qn, Plasma 700014 Glutamate umol/L 20642-5
700068 Amino Acid Profile, Qn, Plasma 700015 Glutamine umol/L 20643-3
700068 Amino Acid Profile, Qn, Plasma 700016 Sarcosine umol/L 26613-0
700068 Amino Acid Profile, Qn, Plasma 700017 Alpha-aminoadipate umol/L 26600-7
700068 Amino Acid Profile, Qn, Plasma 700018 Proline umol/L 20655-7
700068 Amino Acid Profile, Qn, Plasma 700019 Glycine umol/L 20644-1
700068 Amino Acid Profile, Qn, Plasma 700020 Alanine umol/L 20636-7
700068 Amino Acid Profile, Qn, Plasma 700022 Citrulline umol/L 20640-9
700068 Amino Acid Profile, Qn, Plasma 700023 Alpha-aminobutyrate umol/L 20634-2
700068 Amino Acid Profile, Qn, Plasma 700024 Valine umol/L 20661-5
700068 Amino Acid Profile, Qn, Plasma 700025 Cystine umol/L 22672-0
700068 Amino Acid Profile, Qn, Plasma 700026 Methionine umol/L 20651-6
700068 Amino Acid Profile, Qn, Plasma 700027 Homocitrulline umol/L 55876-7
700068 Amino Acid Profile, Qn, Plasma 700028 Cystathionine umol/L 26607-2
700068 Amino Acid Profile, Qn, Plasma 700029 Alloisoleucine umol/L 22670-4
700068 Amino Acid Profile, Qn, Plasma 700030 Isoleucine umol/L 20648-2
700068 Amino Acid Profile, Qn, Plasma 700031 Leucine umol/L 20649-0
700068 Amino Acid Profile, Qn, Plasma 700032 Tyrosine umol/L 20660-7
700068 Amino Acid Profile, Qn, Plasma 700033 Phenylalanine umol/L 14875-9
700068 Amino Acid Profile, Qn, Plasma 700034 Argininosuccinate umol/L 32227-1
700068 Amino Acid Profile, Qn, Plasma 700035 Beta-alanine umol/L 26604-9
700068 Amino Acid Profile, Qn, Plasma 700036 Beta-aminoisobutyrate umol/L 26605-6
700068 Amino Acid Profile, Qn, Plasma 700037 Homocystine umol/L 20646-6
700068 Amino Acid Profile, Qn, Plasma 700038 Gamma-aminobutyrate umol/L 26609-8
700068 Amino Acid Profile, Qn, Plasma 700040 Tryptophan umol/L 20659-9
700068 Amino Acid Profile, Qn, Plasma 700041 Hydroxylysine umol/L 26610-6
700068 Amino Acid Profile, Qn, Plasma 700042 Ornithine umol/L 20652-4
700068 Amino Acid Profile, Qn, Plasma 700043 Lysine umol/L 20650-8
700068 Amino Acid Profile, Qn, Plasma 700044 Histidine umol/L 20645-8
700068 Amino Acid Profile, Qn, Plasma 700045 Arginine umol/L 20637-5
700068 Amino Acid Profile, Qn, Plasma 700063 Interpretation 49247-0
700068 Amino Acid Profile, Qn, Plasma 700064 Director Review 72486-4
700068 Amino Acid Profile, Qn, Plasma 700065 Methodology 49549-9
700068 Amino Acid Profile, Qn, Plasma 700066 Amino Acid, Pl N/A

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf