α2-Macroglobulin, Quantitative

CPT: 83883
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Test Details

Synonyms

  • Alpha-2 Macroglobulin
  • AMG

Use

α2-macroglobulin assay is of major significance in the differential diagnosis of nephrotic syndrome, where an elevated α2-macroglobulin:albumin ratio is indicative of postrenal hematuria. In patients with liver cirrhosis and diabetes, the level of α2-macroglobulin is found to be elevated.

Limitations

In hyperfibrinolytic states, after major surgery, in septicemia and severe hepatic insufficiency, the measured levels of α2-macroglobulin are often low. Patients with acute pancreatitis exhibit low serum concentrations that correlate with the severity of the disease.

Methodology

Immunologic

Reference Interval

110−276 mg/dL

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.2 mL (adult), 0.1 mL (pediatric)

Container

Red-top tube or gel-barrier tube

Collection

Separate serum from cells within 30 to 60 minutes after collection. Transfer specimen to a plastic transport tube.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

3 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis (>1000 mg/dL); gross lipemia that cannot be cleared by ultracentrifugation

Clinical Information

References

N Antiserum to Human Alpha-2-Macroglobulin [package insert]. Newark, Del: Dade-Behring Inc. March 1999.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
122135 Alpha-2 Macroglobulins, Qn 1835-8 122136 Alpha-2 Macroglobulins, Qn mg/dL 1835-8

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