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- Smooth Muscle Antibodies
Detection of antibodies aids in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC)
Antiactin antibodies have been reported at low levels in 3% to 18% of sera from the general healthy population. The presence of immune complexes in the patient's sample may produce false positives in this assay. Not all smooth muscle positive samples will have actin antibodies.
Enzyme-linked immunosorbent assay (ELISA)
• Negative: 0−19
• Weak positive: 20−30
• Moderate to strong positive: >30
Actin antibodies are found in 52% to 85% of patients with autoimmune hepatitis or chronic active hepatitis and in 22% of patients with primary biliary cirrhosis.
Red-top tube or gel-barrier tube
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|006643||Actin (Smooth Muscle) Antibody||34661-9||006644||Actin (Smooth Muscle) Antibody||Units||34661-9|