Immunohistochemical Stains

A-ACT

Alpha-1 antichymotrypsin, A-ACT, ACT, A1AT

α₁-Antichymotrypsin; histiocytes; pancreatic pseudopapillary tumor

A-AT

Alpha-1-antitrypsin, A-AT

α₁-Antitrypsin; inherited A-AT deficiency

ACTH

Adrenocorticotropic hormone

Antiadrenocorticotropic hormone; anterior pituitary

Actin−Muscle-specific

Muscle-specific actin, MSA, HHF-35

Skeletal, smooth, and cardiac muscle; myofibroblastic differentiation

Actin−Smooth Muscle (SMA)

Smooth muscle actin

Myofibroblasts; myoepithelial cells

AE1

Cytokeratin AE1

Cytokeratin AE1; epithelial marker

AE1/AE3

Cytokeratin AE1/AE3

Screening cytokeratin cocktail; epithelial marker

AE3

Cytokeratin AE3

Cytokeratin AE3; high molecular weight cytokeratin; epithelial marker

AFP

Alpha fetoprotein

α-Fetoprotein (AFP); hepatocellular carcinoma; hepatoid carcinoma; yolk sac tumor

AKT Phosphate

RUO AKT 1; protein kinase B, PKB, Rac-alpha

AKT (protein kinase B)

ALK-1

Anaplastic lymphoma kinase-1

Anaplastic lymphoma kinase-1; anaplastic large-cell lymphoma; inflammatory myofibroblastic tumor; adenocarcinoma of lung subset

Amyloid A

Amyloid A protein

Androgen Receptor

AR

Prostate carcinoma; associated with prognosis and treatment outcome

Annexin A1

Annexin A, Annexin 1, ANXA1

Hairy cell leukemia; myeloid cells

B72.3

TAG72, Breast-3,BRST-3

Simple epithelium; adenocarcinoma; excludes mesothelioma

BCA-225

Breast carcinoma-associated glycoprotein

Breast carcinoma-associated glycoprotein; breast carcinoma and other adenocarcinomas

BCL-1 (Cyclin D1)

Cyclin D1; PRAD-1

Mantle-cell lymphoma; multiple myeloma subset

BCL-1/CD20

Double stain; useful for the diagnosis of mantle cell lymphoma

BCL-2

Follicular lymphoma; other B-cell and T-cell lymphomas; soft tissue tumor

BCL-2/BCL-6

Double stain; useful for the diagnosis of follicular center cell lymphoma, diffuse large-cell type

BCL-6

Follicular center B-cells; follicular lymphoma; DLBCL subset

Ber-EP4

BER-EP4, BerEP4, BEREP4, Ep-Cam, epithelial antigen, CD326, Ep-CAM

Epithelial antigen; carcinoma; differentiates carcinoma from mesothelioma

β-Amyloid

Amyloid beta-protein (A-beta-P); amyloid beta-peptide; A-beta; beta-A4 protein; beta-protein

Alzheimer's disease; senile plaques; neurofibrillary tangles; cerebrovascular deposits

β-Catenin

beta-catenin

Soft tissue lesion; fibromatosis; synovial sarcoma

BG8 (Lewis^Y)

Blood group-related antigen; Lewis Y

Adenocarcinoma; exclude mesothelioma

BOB-1

BOB.1/OBF.1

B-cells

CA 19.9

CA-19.9

Pancreas, GI, ovary, lung, and transitional cell carcinoma

CA 125 (OC125)

OC125, ovarian cancer antigen

Female genital tract; breast carcinoma; other adenocarcinoma, including lung and pancreatobiliary

CAIX

Carbonic anhydrase IX, CA9

Carbonic anhydrase IX; renal cell carcinoma (RCC); distinguish clear cell renal cell carcinoma from other RCC subset

Calcitonin

Thyroid C-cells; medullary carcinoma

Caldesmon

CALD, h-Caldesmon

Smooth muscle and myoepithelial cells

Calponin

CALP

Myoepithelial, myofibroblastic, and smooth muscle cells

Calretinin

CALRET

Mesothelial cells; sex cord stromal tumor; adrenal cortical tumor

CAM 5.2

CK8/18

Low molecular weight cytokeratin 8 and 18; epithelial tumor

CAM 5.2/AE1

Screening cytokeratin cocktail; epithelial tumor

CD1a

Cortical thymocytes; Langerhans cell histiocytosis (LCH); T-ALL subset

CD2

E-rosette receptor; LFA-2

Pan, thymic, and peripheral T-cells; NK cells; neoplastic mast cells

CD3 (M)

CD3 (mono)

CD3 (monoclonal); pan T-cells

CD3 (P)

CD3 (poly)

CD3 (polyclonal); pan T-cells

CD3/CD20

Double stain; useful to distinguish B-cells (CD20⁺) and T-cells (CD3⁺)

CD4

Helper/inducer T-cells; thymocyte and monocyte subsets

CD5

Pan T-cells; B-cell lymphoma subset (B-CLL/SLL and MCL); thymic carcinoma

CD7

Pan T‐cells; NK cells, thymocytes; rare AML

CD8

Suppressor/cytotoxic T‐cells; thymocyte and T‐cell/NK cell subsets; T‐LGL leukemia

CD10

CALLA

CALLA; B-cell and T-cell lymphoma subsets; endometrial stromal cells; renal cell carcinoma subset

CD14

Mature monocytes; some granulocytes; macrophages

CD15

LeuM1

Epithelial, myeloid, and Reed-Sternberg cells; Hodgkin lymphoma

CD20

L26

Pan B-cells

CD21

Follicular dendritic cells; B-cell subset

CD22

Pan B-cells

CD23

BU38, SP23

Follicular dendritic cells; B-cell subset; B-CLL

CD25

Activated T‐ and B‐cells; HCL; ATLL

CD30

Ki-1, BerH2

Reed‐Sternberg cells; anaplastic large‐cell lymphoma; DLBCL subset; Hodgkin lymphoma; embryonal carcinoma

CD31

PECAM, platelet-endothelial cell adhesion molecule-1

Endothelium; vascular neoplasm; plasma cells

CD33

Monocytes; myeloid cells; AML; ALL subset

CD34

Clones: QBEnd/10 and HPCA

Blasts; stem cells; endothelium; GIST; soft tissue tumor subset

CD35

Follicular dendritic cell marker; CR1

Follicular dendritic cells

CD43

MT1 (T-cell)

T-cells; B-cell lymphoma subset (B-CLL/SLL, MCL, Burkitt); plasma and myeloid cells; histiocytes

CD45 (LCA)

LCA, leukocyte-common antigen

Leukocyte common antigen

CD45RA

CD45RA (B-cell marker)

B-cells

CD45RO

CD45RO (T-cell marker), UCHL-1

Activated/memory T-cells; B-cell subset

CD56

N-CAM, LEU-6

Neural and neuroendocrine tumor; soft tissue tumor subset; NK cells; plasma and T-cell subsets; LGL leukemia

CD57

HNK‐1, LEU‐7

Neural and neuroendocrine tumor; thymoma; NK cells; T-LGL leukemia; T-cell subset

CD61

GPIIIA

Megakaryocytes; platelets

CD68

KP-1

Histiocytes; macrophages

CD71

Erythroid precursors and large-cell lymphoma; transferrin receptor; activated T- and B-cells; macrophages

CD74

B-cells

CD79a

Pan B-cells

CD99

MIC2, O13

PNET/Ewing sarcoma; soft tissue tumor subset; sex cord stromal tumor

CD117 (c-KIT)

CD117, c-KIT

GIST; subset of carcinoma including adenoid cystic carcinoma; germ cell neoplasm; hematolymphoid neoplasm

CD123

Dendritic cell precursors; type 2 (DC2) cells; blastic plasmacytoid dendritic cell neoplasm (BPDCN)

CD138

Syndecan-1

Plasma cells; subset of epithelial cells

CD163

M130, Ber-Mac3, Ki-M8, SM4

Monocytes; macrophages; dendritic interstitial cells

CDX-2

Enteric differentiation; GI tumor; colorectal carcinoma; carcinoid tumor subset

CDX-2/CK-7

Double stain; useful to distinguish stomach and colon carcinoma from breast, lung, and ovarian carcinoma

CEA (M)

Carcinoembryonic antigen (mono)

Carcinoembryonic antigen (monoclonal); adenocarcinoma

CEA (P)

Carcinoembryonic antigen (poly)

Carcinoembryonic antigen (polyclonal); epithelial marker; adenocarcinoma subset; negative in mesothelioma

Chromogranin A

CHROM

Neuroendocrine neoplasm; paraganglioma

Chymotrypsin

Exocrine pancreas; acinar cell tumor

CK-5

Cytokeratin 5

Tumor with squamous differentiation; squamous cell vs adenocarcinoma of lung classification; myoepithelial cells; benign vs malignant breast intraductal proliferation

CK-5/6

Cytokeratin 5/6

Tumor with squamous differentiation; squamous cell vs adenocarcinoma of lung classification; myoepithelial cells; benign vs malignant breast intraductal proliferation

CK-7

Cytokeratin 7

Various subtypes of carcinoma; frequently used in conjunction with CK-20 for tumor profiling

CK-7/TTF-1

Double stain; useful for the diagnosis of lung adenocarcinoma

CK-14

Cytokeratin 14

High molecular weight cytokeratin; tumor with squamous differentiation; myoepithelial cells; breast carcinoma with basal-like phenotype

CK-17

Cytokeratin 17

High molecular weight cytokeratin; tumor with squamous differentiation; pancreatobiliary adenocarcinoma; breast carcinoma with basal-like phenotype

CK-18

Cytokeratin 18

Low molecular weight cytokeratin

CK-19

Cytokeratin 19

Epithelial tumor; papillary carcinoma of the thyroid vs benign thyroid lesion

CK-20

Cytokeratin 20

Subset of carcinoma; reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells

CK-HMW (34βE12)

Cytokeratin−high molecular weight, keratin 903, CK903, CK34bE12, 34betaE12

CK-903; broad-spectrum high molecular weight cytokeratin; squamous cell and subsets of adenocarcinoma and transitional cell carcinoma; prostate basal cells; prostate carcinoma vs adenosis/PIN

CK-LMW (35βH11)

Cytokeratin−low molecular weight, CK35bH11, CK8, 35betaH11

CK-8; epithelial neoplasm with simple epithelium

CMV−IHC

Cytomegalovirus by IHC

Cytomegalovirus

COLL-IV

Collagen IV

Collagen type IV; basement membrane material; soft tissue tumor subset

COX-2

Cyclooxygenase-2

Cyclooxygenase-2; prognostic and predictive marker in a variety of tumors

D2-40

Podoplanin

Evaluation of lymphatic endothelial differentiation for lymphatic invasion; subset of angiosarcoma; vascular tumor of lymphatic origin; mesothelioma

DBA44 (HCL)

DBA.44, HCL

Hairy cell leukemia

Desmin

DES

Striated and smooth muscle; leiomyosarcoma; rhabdomyosarcoma; desmoplastic small round cell tumor

DOG1

GIST, in particular CD117-negative lesion

EBER−ISH

EBV by ISH; Epstein-Barr virus

Epstein-Barr early RNA; Epstein-Barr virus identification

EBV (LMP1)

Epstein-Barr virus

Epstein-Barr virus; latent membrane protein

E-Cadherin

E-CAD

Ductal vs lobular lesion of breast; positive in ductal lesion and negative in lobular neoplasia

EGFR

Epidermal growth factor receptor, erbB-1, HER-1, EGF-R

Epidermal growth factor receptor; colon and lung carcinoma; basal-phenotype breast carcinoma

EMA

Epithelial membrane antigen, MAM6, MFGMP

Epithelial membrane antigen; epithelial marker; subset of sarcoma, meningioma, and hematolymphoid neoplasm

ER

Estrogen receptor

Estrogen receptor; predictive of endocrine therapy response in breast carcinoma; lower female genital tract carcinoma; endometrial stromal neoplasm; soft tissue lesion subset

ERCC1

Excision repair cross-complementation group 1

Excision repair cross-complementation group 1; lung carcinoma; predictive indicator for cisplatin therapy

Factor VIII (vWF)

Von Willebrand factor, vWF

Von Willebrand factor; endothelial marker; vascular neoplasm; blast cells in acute megakaryocytic leukemia

Factor XIIIa

Factor XIII, F13a

Dermal dendrocytes and dendritic interstitial cells; used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans; fibrohistiocytic neoplasm

Fascin

Hodgkin and Reed-Sternberg cells

FLI-1

Endothelial vascular cells/tumor; Ewing sarcoma/PNET; lymphoblastic lymphoma/leukemia

FSH

Follicle stimulating hormone

Follicular-stimulating hormone; anterior pituitary

Galectin-3

GAL3

Benign vs malignant thyroid follicular neoplasm, in particular papillary carcinoma

Gastrin

Gastric carcinoid; pancreatic endocrine neoplasm subset

GCDFP-15

Gross cystic disease fluid protein 15, BRST-2

Gross cystic disease fluid protein-15; breast carcinoma; salivary and sweat gland neoplasm

GFAP

Glial fibrillary acidic protein

Glial fibrillary acidic protein; glioma; lesion with glial differentiation; salivary gland tumor; neural neoplasm subset

Glucagon

GLU

Pancreatic endocrine neoplasm

Glycophorin A

GPH-A

Erythroid cells

Glypican-3

GPC3

Hepatocellular carcinoma; germ cell tumor; yolk sac tumor

Granzyme B

Cytotoxic T-cell subset; NK cells

Growth Hormone (GH)

GH, hGH

Growth hormone; anterior pituitary

GST

Glutathione S-transferase p, GST pi, GST P1

Distinguish Hodgkin disease and histiocytic malignancy from T-cell lymphoma

HAM 56

HAM 56, anti-macrophage, macrophage

Histiocytes

HBME-1

Human mesothelial cell

Mesothelial cells; subset of adenocarcinoma, in particular lower female genital tract origin; papillary carcinoma of the thyroid

HBP (H. pylori)

Helicobacter pylori, H. pylori, HBP

Helicobacter pylori

HCAg

Hepatitis C antigen

Hepatitis C antigen

HCG

Beta-HCG, B-HCG, human chorionic gonadotropin

Human chorionic gonadotropin (beta); germ cell tumor; trophoblastic disease

Hemoglobin A

HgB A, HEMGL AF

Red cell precursors

HEP B CORE (HBcAg)

Hepatitis B core antigen, HBVc, HBcAg

Hepatitis B core antigen; hepatitis B

HEP B SURF (HBsAg)

Hepatitis B surface antigen, HBVs, HBsAg

Hepatitis B surface antigen; hepatitis B

HepPar 1

Hepatocyte

Hepatocellular carcinoma; hepatoid tumor; germ cell tumor

HER2

HER2/neu, c-erb2, Herceptest

HER-2 protein overexpression; FDA-approved test for detection of HER2/neu; prognostic and predictive indicator in breast carcinoma

Herpes I

Herpes simplex virus 1 antigen, HSV-1

Herpes simplex virus type I

Herpes II

Herpes simplex virus II antigen, HSV-II

Herpes simplex virus type II

HHV-8

Human herpesvirus, type 8, HHV8 latent nuclear antigen, LNA

Human herpesvirus 8; Kaposi’s sarcoma; primary effusion lymphoma

HLA-DR

HLA-DR

Human leukocyte antigen; MHC class II antigen; B-cells; monocytes; myeloid cells; AML; ALL

HMB-45

Melanosome

Melanoma-associated marker; melanocytic lesion; pecoma

HPL

Human placental lactogen, human chorionic somatomammotropin

Human placental lactogen; intermediate trophoblasts; placental site trophoblastic lesion

HPV−IHC

Human papilloma virus antigen, papillomavirus, HPV IHC

Human papilloma virus

HPV (6/11)−ISH

Human papilloma virus

Low-risk human papilloma virus subtypes

HPV (16/18)−ISH

Human papilloma virus

High-risk human papilloma virus subtypes

HPV (31/33)−ISH

Human papilloma virus

High-risk human papilloma virus subtypes

HPV WSS−ISH

Human papilloma virus

Human papilloma virus wide screen; subtypes (6, 11, 16, 18, 30, 31, 33, 35, 45, 51, 52)

HPV High−ISH

Human papilloma virus, high risk by ISH, HPV III, HPV HR (16/18)

Human papilloma virus probe cocktail; subtypes (16, 18, 31, 33, 35, 45, 51, 52, 56, 58, 59, 68, 70); types 16 and 18 are associated with cervical, vaginal, and vulvar malignancies

HPV Low−ISH

Human papilloma virus, low risk by ISH, HPV II, HPV LR (6/11)

Human papilloma virus probe cocktail; subtypes (6, 11, 42, 43, 44); types 6 and 11 are associated with benign diseases (ie, genital warts)

HPV High & Low−ISH

Human papilloma virus, high risk and low risk by ISH

Human papilloma virus high-and-low-probe cocktails; subtypes (6, 11, 16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, 58, 59, 68, 70)

IgA

Immunoglobulin A, alpha-heavy chain

Immunoglobulin A heavy chain

IgD

Immunoglobulin D, kappa-heavy chain

Immunoglobulin D heavy chain

IgG

Immunoglobulin G, gamma-heavy chain

Immunoglobulin G heavy chain

IgG4

MRQ-44

IgG4-related sclerosing disease

IgM

Immunoglobulin M, mu-heavy chain

Immunoglobulin M heavy chain

Inhibin

Inhibin alpha

Sex cord stromal and adrenal cortical tumor; steroid lesion of the ovary

Insulin

Pancreatic endocrine neoplasm

JC Virus−ISH

JC (PML)

Progressive multifocal leukoencephalopathy virus

Kappa−IHC

Kappa light chain immunoglobulin

Immunoglobulin light chain; B-cells and plasma cells

Kappa−ISH

Kappa by ISH

Immunoglobulin light chain; B-cells and plasma cells - RNA

KER, PAN

Pan-cytokeratin (AE1/AE3/PCK26), NY utilizes Pan-cytokeratin as AE1/AE3

Broad-spectrum cytokeratin cocktail

Ki-67

Ki67

Cell proliferation marker

Lambda−IHC

Lambda light chain immunoglobulin

Immunoglobulin light chain; B-cells and plasma cells

Lambda−ISH

Lambda by ISH

Immunoglobulin light chain; B-cells and plasma cells - RNA

LH

Luteinizing hormone

Luteinizing hormone; anterior pituitary

Lipase

Exocrine pancreas; acinar cell tumor

Lysozyme (MURA)

MURA, muramidase

Muramidase; AML; granulocytic sarcoma; histiocytic differentiation

Mammaglobin

MAM

Breast carcinoma; salivary gland lesion and sweat gland neoplasm

MART-1

NY utilizes clone M2-7C10+M29E3

Melanoma-associated marker

MBP

Myelin basic protein

Myelin basic protein; mucin; pancreatic carcinoma vs chronic pancreatitis; colorectal carcinoma; endometrial carcinoma; Barrett's esophagus

M-Cell Tryptase

Tryptase, mast cell tryptase

Mast cells

MEL-5

Melanoma-associated marker

Melan-A

MART-1, MELAN-AIS, NY utilizes clone A103

Melanoma-associated marker; melanocytic lesion and adrenal cortical neoplasm; pecoma

Melan-A/Ki-67

Double stain; useful to distinguish malignant melanoma from benign melanocytic proliferation

Mesothelin

Meso

Mesothelioma

MiTF

Microphthalmia associated transcription factor, MiTF

Malignant melanoma; melanocytic lesion

MLH-1

hMLH-1

DNA mismatch repair protein

MOC-31

MOC-31, epithelial-related antigen

Epithelial differentiation; adenocarcinoma vs mesothelioma

MPO

Myeloperoxidase, MPX

Myeloperoxidase; AML; granulocytic sarcoma

MSH-2

hMSH2

DNA mismatch repair protein

MSH-6

hMSH6

DNA mismatch repair protein

MUC1

Pancreatobiliary and extra-pancreatobiliary non-mucinous adenocarcinoma

MUC2

Colorectal adenocarcinoma and mucinous adenocarcinoma of various sites

MUC4

Epithelial tumor (breast, lung, cervix); pancreatic carcinoma

MUC5AC

Muc-5AC glycoprotein

MUC5AC glycoprotein; distinguish primary mucinous ovarian tumor from colonic carcinoma metastatic to the ovary

MUM-1

MUM1, IRF4, multiple myeloma 1, PIP

Plasma cells; post-germinal B-cells; activated T-cells; Reed-Sternberg cells; DLBCL subset

MYO DI

MyoD1

Rhabdomyosarcoma

Myogenin

Rhabdomyosarcoma

Myoglobin

Rhabdomyosarcoma

Myosin Heavy Chain

SMM-HC, SMM, myosin smooth muscle

Smooth-muscle myosin heavy chain; breast myoepithelial cells

Napsin A

NAPSA

Lung adenocarcinoma

NB84a

Neuroblastoma tumor cells (for bone marrow aspirate and stem cell products, fresh specimen only)

NEU-N

Neuronal differentiation

NF

Neurofilament

Neurofilament; Merkel cells and neural tumor

NK1-C3

NK1/C3, NKI, melanoma-associated antigen

Melanoma-associated marker; melanocytic lesion and neurothekeoma

NPM

Nucleophosmin

Nucleophosmin; nucleophosmin mutations in AML

NSE

Neuron specific enolase

Neuron-specific enolase; present in neurons and neuroendocrine cells (central and peripheral)

OCT-2

B-cell lymphocyte transcription factor; B-cells

OCT-3/4

Testicular germ cell tumor, in particular seminoma and embryonal carcinoma

OSCAR

Anti-cytokeratin (OSCAR)

Broad-spectrum cytokeratin; epithelial lesion

p16

p16, P16INK4A, MTS1, CDKN2

HPV-associated dysplasia/carcinoma (CINtec® p16INK4a)

p21

p21, P21waf1, cip1, Sdi1, Pic1

Tumor suppressor gene

p27/Kip1

p27, p27Kip1

Cyclin-dependent kinase inhibitor

p53

p53

Mutated tumor suppressor gene

p57

KIP2

Molar vs non-molar gestation; distinguish complete hydatidiform mole (CHM) from partial hydatidiform mole (PHM) and hydropic villi

p63

p63

Prostatic basal cells; breast myoepithelial cells; squamous cell carcinoma

p120

p120 catenin

Ductal vs lobular breast lesion; lobular breast carcinoma

P504S

p504S, AMACR, racemase

Prostatic carcinoma and high-grade PIN; subset of renal cell carcinoma

Pan Melanoma

NY/LA utilizes (HMB-45, MART-1, & Tyrosinase); IRV utilizes (MART-1, S100, & Tyrosinase)

Melanoma and melanocytic lesion; pecoma

PANC.POLY

Pancreatic polypeptide, PP

Pancreatic islet-cell tumor subset

Parvovirus B19

Parvovirus B19, PVB19

Parvovirus

PAX-2

Renal cell carcinoma

PAX-5

PAX-5, Pan B-cell

B-cell transcription factor; B-cells; Reed-Sternberg cells; subset of carcinoma including small-cell carcinoma

PAX-5/CD43

Double stain; useful for the identification of CD43- coexpressing B-cell lymphoma

PAX-5/CD5

Double stain; useful for the identification of CD5- coexpressing B-cell lymphoma

PAX-8

Renal cell carcinoma

PC (P. carinii)

Pneumocystis carinii, P. carinii, PCP, PC

Pneumocystis carinii

PD1

Angio immunoblastic T-cell lymphoma (AITL); germinal center T-cells

Perforin

Lymphomas of cytotoxic or NK derivation

PGP 9.5

Protein gene product 9.5

Protein gene product 9.5; neuroendocrine tumor

PLAP

Placental alkaline phosphatase

Placental alkaline phosphatase; germ cell tumor; trophoblastic disease and subset of adenocarcinoma

PMS-2

DNA mismatch repair protein

PR

Progesterone receptor, PgR

Progesterone receptor; predictive of endocrine therapy response in breast carcinoma; lower female genital tract carcinoma; endometrial stromal neoplasm; soft tissue lesion subset

Prolactin

PL, PRO

Anterior pituitary hormone

PSA

Prostate specific antigen

Prostate-specific antigen; primary and metastatic prostatic neoplasm

PSAP

HPAP, PACP, prostatic acid phosphatase

Prostatic acid phosphatase; primary and metastatic neoplasm; carcinoid tumor subset

PSMA

PSM, FOLH, GCP2

Prostate adenocarcinoma

PTEN

MMAC, TEP1

Cowden syndrome; carcinoma of the bladder, breast, endometrium, head and neck, kidney, lung, prostate, stomach, and thyroid; glioblastoma; melanoma

PTH

Parathyroid hormone

Parathyroid hormone; parathyroid neoplasm

PTS

Prostate triple stain, TriView™ Prostate

Prostate triple stain (P504S, p63, CK903); useful for the diagnosis of PIN/adenosis vs prostate carcinoma

RB

Retinoblastoma

Retinoblastoma gene protein; retinoblastoma

RCC (PNRA)

RCC, PNRA, renal cell carcinoma antigen, gp200

Renal cell carcinoma

S6

s6

Correlates with an increase in translation, particularly mRNAs with an oligopyrimidine tract

S100

S-100

Neural tumor; melanoma; chondrocytes; epithelial neoplasm subset

Serotonin

SERO

Carcinoid; pancreatic endocrine neoplasm

Somatostatin

SOMA

Somatostatin; islet cell tumor; carcinoid; pancreatic endocrine neoplasm

Surfactant (SP-A)

SP-A, surfactant protein A, surfactant apoprotein A (SP-A), PE10

Surfactant protein A; lung adenocarcinoma

Synaptophysin

SYN

Neural and neuroendocrine-derived tumor

Synuclein

Alpha-synuclein

Neurodegenerative diseases (synucleinopathies); Parkinson's disease

TAU

Neurofibrillary tangles; Lewy bodies

TCL-1

Ewing sarcoma/PNET; blastic plasmacytoid dendritic cell neoplasm (BPDCN)

TCR β

TCR beta F1

Alpha-beta T-cells

TdT

Terminal deoxynucleotidyl transferase

Terminal deoxynucleotidyl transferase; cortical thymocytes; B-ALL; T-ALL

Thrombomodulin

CD141, TM, CD141, Thrombo

Mesothelial cells; mesothelioma; lymphatic and vascular tumor

Thyroglobulin

THYRO, TGB

Follicular and papillary carcinoma of the thyroid

TIA-1

T-cell intracytoplasmic antigen

T-cell intracytoplasmic antigen; cytotoxic T-cell subset

TOXO

Toxoplasma gondii, toxoplasmosis

Toxoplasmosis

TRAP

Tartrate-resistant acid phosphatase

Tartrate-resistant acid phosphatase; hairy cell leukemia

TriView™ Breast

Breast triple stain, breast microinvasion, CK5/p63/LMW

Breast triple stain (CK5/p63/LMW); useful to differentiate DCIS from microinvasive breast carcinoma; differentiate radial scar from infiltrating carcinoma

TriView™ Prostate

PTS, PIN4, PIN 4 cocktail

Prostate triple stain (P504S, p63, CK903); useful for the diagnosis of PIN/adenosis vs prostate carcinoma

Trypsin

Exocrine pancreas; acinar cell tumor

TS

Thymidylate synthase

Thymidylate synthase; prognostic and predictive indicator for 5-FU-based chemotherapy in colorectal carcinoma

TSH

Thyroid stimulating hormone

Thyroid-stimulating hormone; anterior pituitary

TTF-1

Thyroid transcription factor-1, TTF

Thyroid transcription factor-1; lung and thyroid carcinoma; subset of small cell carcinoma

Tyrosinase

Tyro

Malignant melanoma; melanocytic lesion

Ubiquitin

Neurofibrillary tangles; Lewy bodies

Uroplakin

Uroplakin III, UPIII

Urinary tract transitional cell carcinoma (primary and metastatic)

VEGF

Vascular endothelial growth factor, vascular permeability factor (VPF), VEGFR

Vascular endothelial growth factor; stimulates endothelial cell proliferation; induces microvessel permeability; prognostic indicator

Villin

Differentiate gastrointestinal adenocarcinoma, neuroendocrine carcinoma, and ovarian adenocarcinoma from other adenocarcinoma; label Merkel cells of the skin

Vimentin (VIM)

Mesenchymal neoplasms; malignant melanoma and subsets of carcinoma and lymphoma

VIP

Vasoactive intestinal polypeptide

Vasoactive intestinal polypeptide; pancreatic endocrine neoplasm

VZV

Varicella-Zoster virus

Varicella-Zoster virus

WT1 (M) N-Terminus

Wilms' tumor protein

Wilms' tumor protein; mesothelial cells; malignant mesothelioma; ovarian adenocarcinoma; sex cord stromal tumor of the ovary; endometrioid stromal neoplasm

WT1 (P) C-Terminus

Wilms' tumor protein

Wilms' tumor protein carboxyl terminal; desmoplastic small round cell tumor

ZAP-70

T-cells; CLL/SLL prognosis