Gonadotropin-releasing Hormone Stimulation

Gonadotropin-releasing Hormone Stimulation

Rationale: This test has been used in the diagnosis of central precocious puberty (CPP) and in the differentiation of CPP from other causes of precocious puberty.1,2 The test has also been used to monitor the effectiveness of gonadotropin-releasing hormone (GnRH) analogue therapy.3 In early childhood, the hypothalamic-pituitary-gonadal axis is inhibited, delaying the onset of reproductive maturity. Puberty occurs as increased secretion of GnRH by the hypothalamus produces an increase in pituitary secretion of gonadotropins. Gonadotropin response, especially that of luteinizing hormone (LH), to exogenous GnRH is markedly enhanced after the onset of puberty. A pubertal response has been defined as an LH level after GnRH stimulation >8 IU/L.2

Protocol: GnRH (100 μg) is administered intravenously. A sample for serum LH should be collected at 40 minutes after GnRH administration.4

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