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MYOMARKER ® PROFILE

Myositis

Comprehensive, Innovative Profile and Tests to Help Identify Inflammatory Myopathies

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Inflammatory Myopathies

Idiopathic inflammatory myopathies (IIM), commonly known as myositis, are rare conditions that can affect multiple organs apart from muscle and often lead to a severe impairment of the quality of life.

Diagnosis and treatment are often challenging and usually require testing of auto-antibodies.1

Labcorp offers a myositis profile performed using RIPA and EIA methodologies. MyoMarker® 3 Plus profile includes both myositis-specific antibodies (MSA) and myositis-associated antibodies (MAA), as well as anti-SAE-1 antibody.

Clinical Utility

IIMs are a heterogeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical associations that fall into two main groups:

Myositis-specific autoantibodies (MSA)*

MSA are highly specific for patients with polymyositis (PM), dermatomyositis (DM), anti-synthetase syndrome, and necrotizing myositis

MSAs Methodologies and Clinical Associations(Opens in a new window)

Myositis-associated autoantibodies (MAA)*

MAA appears in myositis overlap syndromes and in other connective tissue diseases, which correlate with certain clinical and/or pathophysiological conditions

MAAs Methodologies and Clinical Associations(Opens in a new window)

Other Myositis-specific autoantibodies (MSA)*

  • Anti-HMGCR Ab
  • Anti-cN-1A Ab (NT5c1A) IBM (RDL)
Other Myositis-specific autoantibodies (MSA)(Opens in a new window)

*Individual components can be ordered separately 

Myositis Profile and Related Testing

 

MyoMarker® 3 Plus Profile includes both myositis-specific antibodies and myositis-associated antibodies, as well as anti-SAE-1 antibody.

MSA are found only in patients with myositis and have been shown to be highly specific for patients with polymyositis (PM), dermatomyositis (DM), anti-synthetase syndrome, necrotizing myositis and overlap syndromes. MAA can be found in patients with overlap syndromes such as polymyositis/scleroderma and may also be found in non-overlap syndromes.

Labcorp offers MyoMarker® 3 Plus Profile performed using RIPA and EIA methodologies.

RIPA gel radiography utilizes immunoprecipitation, gel electrophoresis and autoradiography to identify radioisotope-labeled proteins from human erythroleukemic cell extracts that are targeted by autoantibodies in patient serum. RIPA gel radiography is a powerful, reliable technology that has been used and refined for more than 30 years to identify many PM/DM autoantibodies with high sensitivity, specificity and reproducibility. It is the original methodology of studies that defined various myositis-specific and myositis-associated antibodies.2

 

Other Myositis-Specific Antibodies

Anti-HMGCR Ab (RDL)

Anti-cN-1A Ab (NT5c1A) IBM (RDL)

 

Number Name
520085 MyoMarker® 3 Plus Profile (RDL)
Myositis-Specific Antibodies Myositis-Associated Antibodies

Anti-Jo-1

Anti-PL-7

Anti-PL-12

Anti-EJ

Anti-OJ

Anti-SRP

Anti-Mi-2

Anti-TIF-1gamma (part of P155/140 Kd)

Anti-MDA-5-Ab (CADM-140)

Anti-NXP-2 (P140)

Anti-SAE-1

Anti-PM/Scl-100

Anti-SS-A 52kD

Anti-Ku

Anti-U1 RNP

Anti-U2 RNP

Anti-U3 RNP (Fibrillarin)

 

Labcorp offers legacy RDL MyoMarker® 3 Plus Profile to help identify inflammatory myopathies

View test details