Developmental and Reproductive Toxicology (DART)

Yes. Our experienced DART scientists—including global leaders in the field—offer early design consultation, IND enabling guidance, and support in aligning your approach with current regulatory expectations, including the use of qualified NAMs.

devTOX quickPredict delivers early, human‑relevant developmental toxicity insight using a pluripotent stem‑cell assay and the quantitative O/C biomarker—helping you quickly prioritize candidates, shape smarter study designs, and strengthen your overall weight‑of‑evidence package.

As a qualified NAM under ICH S5(R3), devTOX quickPredict can also inform or defer in vivo developmental toxicity testing, and when scientifically supported, replace one of the two required species in embryo‑fetal development (EFD) studies—reducing animal use while maintaining regulatory confidence.

Through welfare driven, EU compliant housing, our validated Three Pillar Approach, and deep NHP DART expertise, we maintain strong conception rates and reduce pre and post natal losses—helping protect your timelines and study integrity.

You benefit from a fully integrated workflow, global GLP capacity, specialized NHP expertise, and advanced technologies—all working together to reduce risk, maintain momentum, and deliver the clarity you need to make confident development decisions.

We offer comprehensive small model DART work (rodents, rabbits), extensive NHP expertise (including pregnant NHPs), and specialized juvenile model programs to meet modern regulatory expectations.

You can incorporate un sedated ultrasound imaging, continuous infusion (even in small models), advanced behavioral monitoring (e.g., EthoVision), and enriched housing configurations that enhance data quality and reduce confounders.

Labcorp provides end to end DART coverage, including early NAM based screening (devTOX quickPredict), SEG I–III studies, embryo fetal development, enhanced pre and post natal development (ePPND), juvenile studies, and specialty techniques such as infusion and advanced imaging.

NAMs such as devTOX quickPredict are most valuable during early candidate selection, lead optimization, and pre IND planning. They help identify developmental toxicity signals upfront, reducing late stage failures and unnecessary animal studies.