Cytochrome P450 2C9 Genotyping Siponimod

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Synonyms

  • CYP2C9
  • Mayzent
  • Novartis
  • P450 CYP2C9
  • Siponimod

Special Instructions

Samples sent to Monogram for testing.


Expected Turnaround Time

6 - 10 days


Related Documents


Specimen Requirements


Specimen

Whole blood or Labcorp buccal swab kit (buccal swab collection kit contains instructions for use of a buccal swab)


Volume

5 mL whole blood or Labcorp buccal swab kit


Minimum Volume

3 mL whole blood or two buccal swabs


Container

Lavender-top (EDTA) tube or yellow-top (ACD) tube or buccal swab kit


Collection

Collect specimen in a lavender-top (EDTA) tube or yellow-top (ACD) tube or use a buccal swab kit. Ship whole blood specimen at room temperature or frozen. Ship buccal swab collection kit at room temperature.


Storage Instructions

Maintain whole blood specimen at room temperature or refrigerated for 7 days, frozen for 2 years. Maintain buccal swabs at room temperture or refrigerated for 2 months.


Causes for Rejection

Hemolysis; quantity not sufficient for analysis; improper container; single buccal swab; wet buccal swab


Test Details


Use

CYP2C9 genotype testing is required to determine candidacy and the appropriate maintenance dosage for siponimod before treatment initiation. Siponimod is contraindicated in patients who have a CYP2C9*3/*3 genotype. Refer to the siponimod package insert for more details.


Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Real-time polymerase chain reaction (RT-PCR)


References

Siponimod [package insert]. East Hanover, NJ: Novartis Pharmaceutical Corporation; 2019.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
512215 CYP2C9 Genotyping Siponimod 46724-1 512216 2C9 Genotype 46724-1
512215 CYP2C9 Genotyping Siponimod 46724-1 512217 Interpretation 79716-7
512215 CYP2C9 Genotyping Siponimod 46724-1 512218 Director Review: 69965-2
512215 CYP2C9 Genotyping Siponimod 46724-1 512219 PDF 51969-4
512215 CYP2C9 Genotyping Siponimod 46724-1 000000 MGRM Informed Consent Review N/A

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