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Cytochrome P450 2C9 Genotyping Siponimod

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  • CYP2C9
  • Mayzent
  • Novartis
  • P450 CYP2C9
  • Siponimod

Special Instructions

Samples sent to Monogram for testing.

Expected Turnaround Time

6 - 10 days

Related Documents

Specimen Requirements


Whole blood


7 mL

Minimum Volume

3 mL


Lavender-top (EDTA) tube or yellow-top (ACD) tube


Collect specimen in two lavender-top (EDTA) tubes or two yellow-top (ACD) tubes. Ship specimen at room temperature.

Storage Instructions

Room temperature, refrigerated, or frozen

Causes for Rejection

Quantity not sufficient for analysis; improper container

Test Details


CYP2C9 genotype testing is required to determine candidacy and the appropriate maintenance dosage for siponimod before treatment initiation. Siponimod is contraindicated in patients who have a CYP2C9*3/*3 genotype. Refer to the siponimod package insert for more details.


This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Real-time polymerase chain reaction (RT-PCR)


Siponimod [package insert]. East Hanover, NJ: Novartis Pharmaceutical Corporation; 2019.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
512215 CYP2C9 Genotyping Siponimod 46724-1 512216 2C9 Genotype 46724-1
512215 CYP2C9 Genotyping Siponimod 46724-1 512217 Interpretation 79716-7
512215 CYP2C9 Genotyping Siponimod 46724-1 512218 Director Review: 69965-2
512215 CYP2C9 Genotyping Siponimod 46724-1 512219 PDF 51969-4
512215 CYP2C9 Genotyping Siponimod 46724-1 000000 MGRM Informed Consent Review N/A

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