Synonyms
- CYP2C9
- Mayzent
- Novartis
- P450 CYP2C9
- Siponimod
Special Instructions
Samples sent to Monogram for testing.
Expected Turnaround Time
6 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Whole blood or Labcorp buccal swab kit (buccal swab collection kit contains instructions for use of a buccal swab)
Volume
5 mL whole blood or Labcorp buccal swab kit
Minimum Volume
3 mL whole blood or two buccal swabs
Container
Lavender-top (EDTA) tube or yellow-top (ACD) tube or buccal swab kit
Collection
Collect specimen in a lavender-top (EDTA) tube or yellow-top (ACD) tube or use a buccal swab kit. Ship whole blood specimen at room temperature or frozen. Ship buccal swab collection kit at room temperature.
Storage Instructions
Maintain whole blood specimen at room temperature or refrigerated for 7 days, frozen for 2 years. Maintain buccal swabs at room temperture or refrigerated for 2 months.
Causes for Rejection
Hemolysis; quantity not sufficient for analysis; improper container; single buccal swab; wet buccal swab
Test Details
Use
CYP2C9 genotype testing is required to determine candidacy and the appropriate maintenance dosage for siponimod before treatment initiation. Siponimod is contraindicated in patients who have a CYP2C9*3/*3 genotype. Refer to the siponimod package insert for more details.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Real-time polymerase chain reaction (RT-PCR)
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 512215 | CYP2C9 Genotyping Siponimod | 46724-1 | 512216 | 2C9 Genotype | 46724-1 | |
| 512215 | CYP2C9 Genotyping Siponimod | 46724-1 | 512217 | Interpretation | 79716-7 | |
| 512215 | CYP2C9 Genotyping Siponimod | 46724-1 | 512218 | Director Review: | 69965-2 | |
| 512215 | CYP2C9 Genotyping Siponimod | 46724-1 | 512219 | 51969-4 | ||
| 512215 | CYP2C9 Genotyping Siponimod | 46724-1 | 000000 | MGRM Informed Consent Review | N/A |
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