Cystatin C

CPT: 82610
Print Share

Expected Turnaround Time

3 - 5 days

Related Documents

Specimen Requirements


Serum or plasma


0.5 mL

Minimum Volume

0.2 mL


Red-top tube, gel-barrier tube, or green-top (heparin) tube


Separate serum or plasma from red blood cells.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Specimen other than serum or heparinized plasma; grossly hemolyzed (>1,000 mg/dL Hgb) samples; excessive turbidity and clots in samples

Test Details


Since it is formed at a constant rate and freely filtered by the healthy kidney, cystatin C is a good marker of renal function. Serum concentrations of cystatin C are almost totally dependent on glomerular filtration rate (GFR).1,2 A reduction in GFR causes a rise in the concentration of cystatin C.


Cystatin C has not been shown to be affected by factors such as muscle mass and nutrition, factors which have been demonstrated to affect creatinine values. In addition, a rise in creatinine does not become evident until the GFR has fallen by approximately 50%.


Turbidimetric (directly traceable to ERM-DA471/IFCC, the international standard reference material)

Reference Interval

See table.


Range (mg/L)

0 to 1 y

Not established

2 to 50 y


51 to 60 y


61 to 70 y


71 to 80 y


>80 y



1. Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol. 1992; 38(Suppl 1):S20-7. 1284235
2. Coll E, Botey A, Alvarez L, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000; 36:29-34.10873868


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
121251 Cystatin C 33863-2 121252 Cystatin C mg/L 33863-2

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at