Helicobacter pylori Antibodies, IgA, IgG, IgM

CPT: 86677(x3)
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Test Details

Synonyms

  • Anti-Campylobacter Antibodies
  • Anti-H pylori Antibodies

Use

Aid in the diagnosis of acute and chronic H pylori infections in patients with gastric and duodenal disease. Current studies suggest that H pylori IgM testing should be performed concomitantly with H pylori IgA and/or IgG tests for accurate diagnosis of Helicobacter pylori infection.

Limitations

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). Results of this test are for investigational purposes only. The results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically diagnostic product or procedure.

Methodology

H pylori IgA and IgM: enzyme-linked immunosorbent assay (ELISA); H pylori IgG: chemiluminescence

Reference Interval

See individual tests.

Additional Information

Circulating antibodies to H pylori are predominantly of the IgG class. A systemic response of the IgA type is usually less pronounced but if significant, may indicate an early infection. Antibodies to IgG are the most useful for monitoring treatment.

Specimen Requirements

Specimen

Serum

Volume

2 mL

Minimum Volume

1 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

3 days

Refrigerated

3 days

Frozen

7 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Heat inactivated serum; hemolysis; lipemia; gross bacterial contamination

Clinical Information

References

Kosunen TU, Seppälä K, Sarna S, Sipponen P. Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori.Lancet. 1992 Apr 11; 339(8798):893-895. 1348298
Thomson ABR. Helicobacter pylori and gastroduodenal pathology. Can J Gastroenterol. 1993; 7(4):353-358.
von Wulffen H. An assessment of serological tests for the detection of Helicobacter pylori.Eur J Clin Microbiol Infect Dis. 1992 Jul; 11(7):577-582.1396763

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163683 H pylori, IgM, IgG, IgA Ab 162289 H. pylori, IgG Abs U/mL 5176-3
163683 H pylori, IgM, IgG, IgA Ab 163173 H. pylori, IgA Abs units 7901-2
163683 H pylori, IgM, IgG, IgA Ab 163208 H pylori, IgM Abs units 7903-8
Reflex Table for H pylori, IgM Abs
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163209 Disclaimer: 163209 Disclaimer: N/A

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