Barbiturates, Screen and Confirmation, Urine

CPT: 80307
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Test Details

Test Includes

Identification and confirmation of barbiturates in urine, including amobarbital, butalbital, pentobarbital (Nembutal®), phenobarbital (Luminal®), and secobarbital. Confirmation by mass spectrometry (MS) is automatically performed on positives at an additional charge.

Use

Confirm the presence of barbiturates

Limitations

Short- and intermediate-acting barbiturates can be detected in urine for at least 24 to 72 hours following ingestion, longer-acting drugs for at least seven days.

Methodology

Initial testing by immunoassay (IA); confirmation of positives by mass spectrometry (MS)

Additional Information

The presence of barbiturates in urine is presumptively positive at a level >300 ng/mL using secobarbital as a standard and can indicate prescribed or abused intake of this class of drugs.

Specimen Requirements

Specimen

Urine

Volume

20 mL

Container

Use plastic urine drug bottle and tamper-evident seal for forensic specimen. Collection kits are available by request from the laboratory.

Collection

Urine temperature monitoring is recommended for samples to be tested for medicolegal purposes.

Storage Instructions

Maintain specimen at room temperature. If arrival extends beyond seven days, then refrigerate.

Causes for Rejection

Quantity not sufficient for analysis; improper specimen (serum, plasma, blood); incomplete chain-of-custody documentation; incomplete specimen identification; improper or missing tamper-evident seals

Clinical Information

Special Instructions

Chain-of-custody documentation is required for samples submitted for preëmployment, random employee testing, and forensic purposes. For other applications, use the standard test request form. Please mark chain-of-custody test number on the request form.

References

Blanke RB. In: Tietz NW, ed. Clinical Chemistry. New York, NY: WB Saunders Co;1986:1670-1744.
Kaplan LA, Pesce AJ, eds. Clinical Chemistry—Theory, Analysis, and Correlation. St Louis, Mo: Mosby-Year Book Inc;1989:1081-1087.
Maurer HH. Identification and differentiation of barbiturates and their metabolites in urine. J Chromatogr. 1990 Sep 14; 530(2):307-326. 2079506

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
074419 Barbiturate Screen, Urine 714899 Barbiturate ng/mL 19270-8
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 777012 Barbiturates 3377-9
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 777010 Amobarbital 3339-9
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 071696 Amobarbital GC/MS Conf ng/mL 16239-6
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 777013 Secobarbital 4029-5
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 714485 Secobarbital GC/MS Conf ng/mL 16238-8
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 777014 Butalbital 3421-5
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 714501 Butalbital GC/MS Conf ng/mL 16237-0
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 777015 Pentobarbital 3925-5
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 714543 Pentobarbital GC/MS Conf ng/mL 16240-4
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 777016 Phenobarbital 3949-5
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 714568 Phenobarbital GC/MS Conf ng/mL 16241-2
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 070474 Documentation N/A
Reflex Table for Barbiturate
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 071290 Barbiturate Confirmation, Ur 739264 Barbiturates Holding N/A

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