Calcium:Creatinine Ratio

CPT: 82340; 82570
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Expected Turnaround Time

Within 1 day

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Specimen Requirements


Urine (random)


Use random transport tube or urine Monovette® with pH stabilizer (Labcorp N° 56015). Monovette® instructions accompany units.


Collect urine and transfer to a random urine transport tube or urine Monovette® with pH stabilizer (LabCorp N° 56015). Final pH must be <2.

Storage Instructions

After collection, pH is adjusted to 1.5−2.0 with 6N HCl. Refrigerate.

Stability Requirements



Room temperature

7 days


14 days


7 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Improperly labeled specimen

Test Details


A random urine calcium:creatinine ratio is used to screen for hypercalciuria, as it is found to have a good correlation with 24-hour urine calcium excretion.1 Increased urinary excretion of calcium accompanies hyperparathyroidism, vitamin D intoxication, diseases that destroy bone (such as multiple myeloma), metastasis from prostatic cancer, and following calcium supplementation. Urine calcium is increased with immobilization, with steroid therapy, with Paget disease, and in primary (idiopathic) hypercalciuria.




1. Longman C. Disorders of phosphorus, calcium, and vitamin D. In: Holliday MA, Barrat TM, Avner ED, eds. Pediatric Nephrology. 3rd ed. Baltimore, Md: Williams & Wilkins;1994:619-620.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
134908 Calcium/Creatinine Ratio 9321-1 013490 Calcium, Urine mg/dL 18488-7
134908 Calcium/Creatinine Ratio 9321-1 013672 Creatinine, Urine mg/dL 2161-8
134908 Calcium/Creatinine Ratio 9321-1 134911 Calcium/Creat.Ratio mg/g creat 9321-1

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