Manganese, Urine

CPT: 82570; 83785
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Test Details

Synonyms

  • Mn, Urine

Use

Confirm manganese exposure, toxicity, or poisoning by documenting excessive urine excretion of the metal. Also used to individualize manganese dosing in long-term parenteral nutrition, especially in liver disease, when biliary excretion is low, or when there is excessive gastrointestinal losses, such as in short bowel syndrome. Has been used to follow the success of chelation therapy with para-aminosalicylate sodium in manganism.

Limitations

Levels in urine are so low that considerable error may be introduced by contamination. Manganese toxicity may leave residual neurologic damage after serum and urine levels have returned to normal, masking the original cause.

Methodology

Inductively-coupled plasma/mass spectrometry (ICP/MS)

Reference Interval

Environmental exposure: 0.0−2.9 μg/L1

Additional Information

Manganese poisoning through acute exposure may produce symptoms of fever, muscle pains, chills, and dryness of the mouth and throat. Chronic exposures to manganese may be evidenced by effects on the CNS (eg, headache, restlessness, irritability, personality change, hallucinations, and hearing impairment).2 Levels may be reduced mildly in epilepsy and raised in hepatitis or jaundice.3 Urine manganese is used in conjunction with plasma manganese to evaluate possible toxicity or deficiency of manganese, an essential mineral. High concentrations can cause nausea, headache, and psychiatric disturbances with neurological damage similar to Parkinson disease. Normalization of plasma may not reverse the neurological damage.

Specimen Requirements

Specimen

Urine (random)

Volume

20 mL

Minimum Volume

1.7 mL

Container

Plastic urine container, no preservative

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Clinical Information

Special Instructions

Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.

Footnotes

1. Lauwerys RR, Hoet P. Industrial Chemical Exposure: Guidelines for Biological Monitoring. 2nd ed. Boca Raton, Fla: Lewis Publishers;1993:292.
2. Baselt RC, Cravey RH. Disposition of Toxic Drugs and Chemicals in Man. 4th ed. Chemical Toxicology Institute;1995.
3. Jacobs DS, DeMott WR, Oxley DK, et al. Laboratory Test Handbook With Key Word Index. 5th ed. Hudson, OH: Lexi-Comp Inc; 2001.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
071597 Manganese, Urine 071598 Manganese, Urine ug/L 5684-6
071597 Manganese, Urine 723280 Creatinine(Crt),U g/L 2161-8
071597 Manganese, Urine 071599 Manganese/Crt Ratio ug/g creat 27367-2
Reflex Table for Creatinine(Crt),U
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 723284 Comment: 723284 Comment: N/A

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