Interleukin-8, Serum

CPT: 83520
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Test Details

Synonyms

  • IL-8
  • IL8

Use

Interleukin-8 (IL-8), a member if the neutrophil-specific CXC subfamily of chemokines, is a potent neutrophil chemotactic and activating factor.1 It is a primary inflammatory cytokine produced by many cells (including monocytes/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, astrocytes, and chondrocytes) in response to proinflammatory stimuli such as bacteria and viruses. IL-8 serves to attract neutrophils to the site of inflammation and to activate them.

Limitations

Results of this test are for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Specimen Requirements

Specimen

Serum

Volume

0.5 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection

Separate serum from cells. Transfer serum to a plastic transport tube.

Storage Instructions

Refrigerate; stable for seven days. Stable at room temperature for three days. Stable frozen for 14 days. Freeze/thaw cycles x2.

Causes for Rejection

Gross hemolysis; sample left on cells

Clinical Information

Footnotes

1. Mukaida N, Ketlinsky SA, Matsushima K. Interleukin-8. In: Thomson, AW and Lotze ME, eds. Cytokine Handbook. 4th ed, vol 2. London, UK, and San Diego, Calif: Academic Press, Elsevier Science; 2003: 1049-1081.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
140918 Interleukin-8, Serum 33211-4 140919 Interleukin-8, Serum pg/mL 33211-4

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