Interleukin-4, Serum

CPT: 83520
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Test Details


Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T lymphocytes, CD3+ cells, NK-T cells, mast cells, eosinophils, and basophils.1 IL-4 has multiple immune response modulation functions on a variety of cell types. It is an important regulator of isotype switching, inducing IgE production in B lymphocytes. It is an important modulator of the differentiation of precursor T helper cells to the TH2 subset that mediates humoral immunity and modulates antibody production. In addition, IL-4 has also been shown to have antitumor activity both in vivo and in vitro.1


Results of this test are for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.


Enzyme-linked immunosorbent assay (ELISA)

Specimen Requirements




0.5 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells. Transfer serum to a plastic transport tube.

Storage Instructions

Refrigerate; stable for 14 days. Stable at room temperature or frozen for 14 days. Freeze/thaw cycles x3.

Causes for Rejection

Gross hemolysis; sample left on cells

Clinical Information


1. Okada H, Banchereau J, Lotze MT. Interleukin-4. In: Thomson AW, Lotze MT, eds. Cytokine Handbook. Vol 1, 4th ed. San Diego, Calif: Academic Press; 2003: 227-262.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
140914 Interleukin-4, Serum 27161-9 140915 Interleukin-4, Serum pg/mL 27161-9

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