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In Vitro Safety Assessment for Crop Protection Products

Human-relevant, nonanimal approaches designed to streamline your regulatory journey and strengthen confidence in your crop protection product
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Advance your crop protection product with in vitro data that regulators trust

With more than 20 years of in vitro toxicology experience, Labcorp provides human‑relevant testing strategies that help you answer key toxicology questions faster, more predictively, and more efficiently. Our scientists apply globally recognized, regulator‑aligned methods to strengthen confidence in your crop protection product—whether you’re screening early‑stage leads or preparing for dossier submission.

Purpose built NAM strategies that support your regulatory success

In vitro testing is central to evaluating the potential human health impact of your active ingredient. But with varying regional requirements, evolving endpoints, and rapid regulatory changes, selecting the right NAM strategy is increasingly complex.

Our expertise is shaped by decades of crop protection testing and active participation in international in vitro toxicology bodies—including Society of Toxicology (SOT), Eurotox, British Toxicology Society (BTS), and European Society of Toxicology In Vitro (ESTIV). 

Labcorp helps you:

  • Identify the most efficient in vitro or in silico strategy for your active ingredient
  • Anticipate and address regulatory expectations across EPA, EFSA, PMRA, OECD, and global jurisdictions
  • Reduce uncertainty by generating mechanistic insight earlier
  • Build verifiable weight‑of‑evidence packages aligned with global regulatory standards

Featured in vitro NAM assays

Below are two of our most advanced human‑cell–based NAMs—each offering powerful, mechanism‑informed insight early in your safety program.

ToxTracker®
 

A validated stem‑cell–based reporter assay for genotoxicity mechanism identification

ToxTracker provides highly sensitive detection of genotoxic compounds and differentiates among:

  • Direct DNA reactivity
  • Oxidative stress
  • Protein damage
  • Clastogenic and aneugenic mechanisms

This mechanistic clarity helps de‑risk regulatory interactions by providing deeper insight into how and why a substance triggers genotoxic responses—an advantage recognized by regulators and validation groups.

devTOX quickPredict™ 


A human-cell–based developmental toxicity NAM—NEW

devTOX quickPredict offers mechanism informed developmental toxicity screening at the discovery or early assessment stage. This assay helps you:
 

  • Identify developmental toxicity concerns earlier
  • Prioritize safer or more promising leads
  • Strengthen weight-of-evidence arguments
  • Support 3Rs by reducing unnecessary animal studies

Together, ToxTracker and devTOX quickPredict deliver complementary insight across genotoxicity and developmental toxicity—
supporting smarter, earlier decisions for your crop protection program.

Comprehensive in vitro safety capabilities—aligned with global standards

Labcorp provides a full suite of in vitro toxicology assays tailored to the needs of agrochemical developers. Whether you’re preparing for screening, hazard identification, or dossier submission, you benefit from our depth of scientific, analytical, and regulatory expertise.

Labcorp has helped validate multiple in vitro technologies and remains actively engaged with scientific and regulatory workstreams shaping the future of NAMs. 

Our capabilities include:

  • Genotoxicity and carcinogenicity (ToxTracker, Ames, IVMN, and CTA)

  • Endocrine activity assays

  • Cytotoxicity and phototoxicity
     

  • Sensitization and irritation screening

  • Mechanistic/mode-of-action evaluations

  • Advanced NAM platforms and 3D tissue models

Frequently asked questions

Move forward with a clearer, more efficient in vitro strategy.