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A New AI-Powered Real-World Data Platform for Alzheimer’s

Developed with Amazon Web Services (AWS) and Datavant, the platform provides access to longitudinal laboratory data at scale and advanced analytics to accelerate discovery, streamline drug development, and improve patient outcomes.
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Patients and their families are waiting for answers

Alzheimer’s disease presents one of the greatest scientific and societal challenges of our time. Despite decades of investment and scientific advancement, clinical trials continue to face high failure rates, early detection remains inconsistent, and real-world evidence gaps persist—creating barriers to effective intervention and equitable patient care.

Amid emerging biomarkers, new therapies, and evolving patient pathways, the ability to connect real-world insights at scale has never been more important.

0.0 Americans living with Alzheimer’s today
0 how often a new diagnosis is made
0 failure rate in Alzheimer’s clinical trials
0 annual economic burden in the U.S.

Source: Alzheimer’s Association 2025

Unmatched real-world data scale for Alzheimer's
 

Comprehensive multimodal Alzheimer's data

New biologic tools, blood-based biomarkers, and emerging therapies are reshaping early detection and patient pathways.

Real progress at scale will depend on cloud-enabled diagnostic data that can be accessed, integrated and analyzed in real time. 

  • Blood-based biomarkers in Aβ42/40, pTau181, pTau217, NfL, ATN profiles
  • Genetic risk markers for APOE
  • Co-testing context for metabolic, endocrine, and inflammatory
  • Repeat biomarker testing patterns
  • Real-world care pathways and decision patterns
285K+

patients have undergone Alzheimers's biomarker testing from Labcorp.

Transforming fragmented data into scalable real-world evidence
 

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Track longitudinal patient journeys

Model the full Alzheimer’s disease trajectory using real-world diagnostic and biological patterns.

Identify at risk populations earlier

AI-powered pattern detection can surface risk signals potentially years before symptom onset informing clinical development, trial design, and population health strategies.

Generate regulatory-grade evidence

Demonstrate real-world utilization of biomarker adoption, and therapeutic access patterns that inform payer coverage and Health Technology Assessment submissions.

Inform decision-making across the full product lifecycle

  • Early development

  • Clinical trials

  • HEOR & access

  • Postmarketing surveillance

Example questions the platform answers in seconds
 

  • “Show me Alzheimer's screening rates by age over the past 12 months.”
     

  • “What percentage of patients on anti-amyloid therapies received a blood biomarker test for Alzheimer’s disease?”
     

  • "How many patients within each APOE genotype have pTau217 levels above the defined clinical threshold?"
     

This Alzheimer's real-world data platform is powered by

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Datavant Connect on AWS

Secure, privacy-preserving data linkage

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Amazon Bedrock & AgentCore

An agentic platform that enables operational deployment of AI agents, including natural language queries and advanced analytics

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Labcorp’s linkable data infrastructure

Tokenized, de-identified diagnostic and claims data powering real-world evidence at scale

See it in action

The platform represents a breakthrough in unifying healthcare research, combining Labcorp's extensive diagnostic and genomic datasets with medical claims, and in future versions, electronic health record and social determinants of health data.  

Researchers, payers, and clinicians can extract insights in real time—accelerating decisions that previously involved months of manual preparation and data aggregation.