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NMR LipoProfile® With Lipids and Insulin Resistance Markers (Without Graph)

Test Number 884000
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CPT

80061; 83704
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  • Updated on 06/01/2026

Test Details

Methodology

Nuclear magnetic resonance (NMR)

Note: The NMR method for Triglycerides, unlike the routine chemical method, is not affected by endogenous glycerol, which might be found in very rare clinical conditions such as Hyperglycerolemia (glycerol kinase deficiency-GKD), an X-linked genetic disorder. Large quantitative differences in the chemical and NMR method results may be attributable to high blood glycerol.

Result Turnaround Time

2 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

NMR LipoProfile® Assay Options Table

Test Includes

This test includes: historical reporting (LDL-P, LDL-C); insulin resistance and diabetes risk markers (large VLDL-P, small LDL-P, large HDL-P, VLDL size, LDL size, HDL size); insulin-resistance score; lipoprotein particle number (LDL-P); particle concentration and size (total HDL-P, small LDL-P, LDL size); standard lipid panel (total cholesterol, calculated LDL cholesterol, HDL cholesterol, triglycerides).

Historical reporting (LDL-P, LDL-C); insulin resistance and diabetes risk markers (large VLDL-P, small LDL-P, large HDL-P, VLDL size, LDL size, HDL size); insulin-resistance score; lipoprotein particle number (LDL-P); particle concentration and size (total HDL-P, small LDL-P, LDL size); standard lipid panel (total cholesterol, calculated LDL cholesterol, HDL cholesterol, triglycerides)

This test includes: historical reporting (LDL-P, LDL-C); insulin resistance and diabetes risk markers (large VLDL-P, small LDL-P, large HDL-P, VLDL size, LDL size, HDL size); insulin-resistance score; lipoprotein particle number (LDL-P); particle concentration and size (total HDL-P, small LDL-P, LDL size); standard lipid panel (total cholesterol, calculated LDL cholesterol, HDL cholesterol, triglycerides).

Use

NMR LDL-P is a management tool used in appropriate high-risk patients (type 2 diabetes mellitus, metabolic syndrome, CVD risk equivalent, statin-treated patients) to adjudicate response to treatment and guide adjustment in therapy. It is used in conjunction with other lipid measurements and clinical evaluation to aid in the management of lipoprotein disorders associated with cardiovascular disease.

Limitations

If triglyceride level is >800 mg/dL, LDL cholesterol will not be calculated.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Custom Additional Information

The NMR LipoProfile® test is a blood test that directly measures the amount of LDL circulating in the body. “LDL” is low-density lipoprotein and has long been recognized as a major causal factor in the development of heart disease. Although the relationship of increased LDL particle number and plaque buildup in the artery wall has been known since the 1950s, a diagnostic test did not exist to measure LDL particle number (LDL-P). Historically, LDL cholesterol, or LDL-C, has been used to estimate LDL levels to assess a patient’s LDL-related cardiovascular risk and judge an individual’s response to LDL-lowering therapy. The NMR LipoProfile® test reports results for LDL-P, a more reliable measure of LDL that directly counts the number of LDL particles a patient has using NMR technology.

The Lipoprotein Insulin Resistance Index (LP-IR) is a simple, high-throughput means for assessing a patient’s insulin resistance with scores ranging from 0 (most insulin sensitive) to 100 (most insulin resistant).1 LP-IR scores are calculated by combining the weighted measurements of six lipoprotein parameters that are known to be altered in patients with insulin resistance, metabolic syndrome and type 2 diabetes: large VLDL, small LDL, large HDL particle numbers and VLDL, LDL and HDL diameter size.1 LP-IR scores identify individuals at higher risk of developing type 2 diabetes independent of glucose and body mass index.2-4 LP-IR can support early detection and guide lifestyle or treatment strategies aimed at improving insulin sensitivity and reducing diabetes risk. A clinical cutoff of 68 or higher indicates elevated insulin resistance and increased diabetes risk.2 

For more references, see Test No. 884095 on the Labcorp Test Menu.

Specimen Requirements

Specimen

Spun NMR LipoTube (preferred), serum from a plain red-top tube, plasma from a lavender-top (EDTA-no gel) or green-top (heparin-no gel) tube; keep refrigerated and ship with frozen cool packs

Volume

2 mL

Minimum Volume

1 mL

Container

NMR LipoTube (black-and-yellow-top tube) is the preferred container; plain red-top tube, lavender-top (EDTA-no gel) tube or green-top (heparin-no gel) tube

Collection Instructions

Collect specimen in NMR LipoTube (black-and-yellow-top tube), which is the preferred container. Plain red-top, green-top (heparin-no gel) or lavender-top (EDTA-no gel) tubes also are acceptable. Serum or plasma drawn in gel-barrier collection tubes other than the NMR LipoTube should not be used. The LipoTube is the only acceptable gel-barrier tube. Gently invert tube eight to 10 times to mix contents and allow specimen to clot for 30 minutes upright at room temperature prior to centrifugation (plasma tubes should not clot). Centrifuge specimen within two hours of collection at 1600 to 1800 xg for 10 to 15 minutes to separate serum/plasma from the red cells and to avoid red cell contamination during shipment. If the sample cannot be centrifuged immediately, the sample should be refrigerated (at 2ºC to 8ºC) and centrifuged within 24 hours of collection. Note: Centrifuging the specimen while still cold may negatively affect the migration of the gel to the serum/red cell interface and may increase the likelihood of specimens being contaminated with red cells during shipment. All specimens should be centrifuged by the client prior to shipment to Labcorp to ensure sample integrity. Do not open NMR LipoTube (black-and-yellow-top). Immediately after centrifugation, pipette separated red-top serum or green-top/lavender-top plasma into a transport tube and label accordingly (serum, heparin plasma, EDTA plasma). Keep samples refrigerated until shipment to the laboratory, and ship with frozen cool packs.

Storage Instructions

Refrigerate all acceptable tube types as soon as possible after centrifugation and within 24 hours of collection. Keep refrigerated prior to shipment, and ship on frozen cool packs. Do not store at room temperature. Do not freeze the sample. Sample is stable refrigerated for six days.

Patient Preparation

Patient should be fasting for eight hours.

Causes for Rejection

Unspun specimens; plasma/serum contaminated with red cells; citrated plasma (light blue-top tube); gross hemolysis; specimen received in inappropriate container; specimen stored at room temperature for more than a total preanalytical time of 24 hours; specimen more than six days old

Footnotes

1. Shalaurova I, Connelly MA, Garvey WT, Otvos JD. Lipoprotein insulin resistance index: a lipoprotein particle-derived measure of insulin resistance. Metab Syndr Relat Disord. 2014 Oct;12(8):422-429. PubMed 24959989

2. Flores-Guerrero JL, Connelly MA, Shalaurova I, et al. Lipoprotein insulin resistance index, a high-throughput measure of insulin resistance, is associated with incident type II diabetes mellitus in the Prevention of Renal and Vascular End-Stage Disease study. J Clin Lipidol. 2019 Jan-Feb;13(1):129-137.e1. PubMed 30591414

3. Dugani SB, Akinkuolie AO, Paynter N, Glynn RJ, Ridker PM, Mora S. Association of Lipoproteins, Insulin Resistance, and Rosuvastatin With Incident Type 2 Diabetes Mellitus : Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2016 May 1;1(2):136-145. PubMed 27347563

4. Harada PHN, Demler OV, Dugani SB, et al. Lipoprotein insulin resistance score and risk of incident diabetes during extended follow-up of 20 years: The Women's Health Study. J Clin Lipidol. 2017 Sep-Oct;11(5):1257-1267.e2. PubMed 28733174

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
884000 NMR LipoProfile+Lipids+IR 59062-0 884294 LDL-P nmol/L 54434-6
884000 NMR LipoProfile+Lipids+IR 59062-0 123479 LDL-C (NIH Calc) mg/dL 13457-7
884000 NMR LipoProfile+Lipids+IR 59062-0 123475 HDL-C mg/dL 2085-9
884000 NMR LipoProfile+Lipids+IR 59062-0 123476 Triglycerides mg/dL 2571-8
884000 NMR LipoProfile+Lipids+IR 59062-0 123477 Cholesterol, Total mg/dL 2093-3
884000 NMR LipoProfile+Lipids+IR 59062-0 884296 HDL-P (Total) umol/L 49748-7
884000 NMR LipoProfile+Lipids+IR 59062-0 884297 Small LDL-P nmol/L 43727-7
884000 NMR LipoProfile+Lipids+IR 59062-0 884309 LDL Size nm 17782-4
884000 NMR LipoProfile+Lipids+IR 59062-0 884300 Large VLDL-P nmol/L 43728-5
884000 NMR LipoProfile+Lipids+IR 59062-0 884316 Small LDL-P nmol/L 43727-7
884000 NMR LipoProfile+Lipids+IR 59062-0 884302 Large HDL-P umol/L 43729-3
884000 NMR LipoProfile+Lipids+IR 59062-0 884303 VLDL Size nm 62254-8
884000 NMR LipoProfile+Lipids+IR 59062-0 884317 LDL Size nm 17782-4
884000 NMR LipoProfile+Lipids+IR 59062-0 884305 HDL Size nm 62253-0
884000 NMR LipoProfile+Lipids+IR 59062-0 884314 LP-IR Score 62255-5
884000 NMR LipoProfile+Lipids+IR 59062-0 884310 PDF N/A
884000 NMR LipoProfile+Lipids+IR 59062-0 123469 Historical Reporting N/A
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884294
Result Code NameLDL-P
UofMnmol/L
Result LOINC54434-6
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code123479
Result Code NameLDL-C (NIH Calc)
UofMmg/dL
Result LOINC13457-7
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code123475
Result Code NameHDL-C
UofMmg/dL
Result LOINC2085-9
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code123476
Result Code NameTriglycerides
UofMmg/dL
Result LOINC2571-8
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code123477
Result Code NameCholesterol, Total
UofMmg/dL
Result LOINC2093-3
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884296
Result Code NameHDL-P (Total)
UofMumol/L
Result LOINC49748-7
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884297
Result Code NameSmall LDL-P
UofMnmol/L
Result LOINC43727-7
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884309
Result Code NameLDL Size
UofMnm
Result LOINC17782-4
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884300
Result Code NameLarge VLDL-P
UofMnmol/L
Result LOINC43728-5
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884316
Result Code NameSmall LDL-P
UofMnmol/L
Result LOINC43727-7
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884302
Result Code NameLarge HDL-P
UofMumol/L
Result LOINC43729-3
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884303
Result Code NameVLDL Size
UofMnm
Result LOINC62254-8
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884317
Result Code NameLDL Size
UofMnm
Result LOINC17782-4
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884305
Result Code NameHDL Size
UofMnm
Result LOINC62253-0
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884314
Result Code NameLP-IR Score
UofM
Result LOINC62255-5
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code884310
Result Code NamePDF
UofM
Result LOINCN/A
Order Code884000
Order Code NameNMR LipoProfile+Lipids+IR
Order Loinc59062-0
Result Code123469
Result Code NameHistorical Reporting
UofM
Result LOINCN/A