Test Details
Methodology
Liquid chromatography/tandem mass spectrometry (LC-MS/MS)
Result Turnaround Time
10 - 14 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test is used for therapeutic drug management.
Specimen Requirements
Specimen
Serum or plasma
Volume
3 mL
Minimum Volume
1.2 mL
Container
Red-top tube or green-top (heparin) tube; gel-barrier tubes are not recommended
Collection Instructions
Serum or plasma should be separated from cells within two hours of venipuncture. Submit serum or plasma in a plastic transport tube.
Stability Requirements
| Temperature | Period |
| Room temperature | 21 days |
| Refrigerated | 21 days |
| Frozen | 4 weeks |
| Freeze/thaw cycles | Stable x3 |
Reference Range
Therapeutic range has not been established. Expected steady-state amantadine concentrations in patients receiving recommended daily dosages: 200−1000 ng/mL.
Storage Instructions
Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.
The storage instructions reflect optimal storage conditions for samples that have a typical pathway through preanalytical steps. Stability information is provided to inform decisions for samples that do not follow typical pathways, such as add-on testing days after collection.
Patient Preparation
Trough levels are most reproducible.
Causes for Rejection
Gel-barrier tubes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 808399 | Amantadine (Symmetrel) | 3317-5 | 808400 | Amantadine | ng/ml | 3317-5 |
| Order Code | 808399 | |||||
| Order Code Name | Amantadine (Symmetrel) | |||||
| Order Loinc | 3317-5 | |||||
| Result Code | 808400 | |||||
| Result Code Name | Amantadine | |||||
| UofM | ng/ml | |||||
| Result LOINC | 3317-5 |