Sirolimus, Whole Blood

CPT: 80195
Print Share


  • Rapamune®

Expected Turnaround Time

2 - 4 days

Related Documents

Specimen Requirements


Whole blood


3 mL

Minimum Volume

1.1 mL


Lavender-top (EDTA) tube


Trough: 30 minutes to one hour before the next oral dose

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Patient Preparation

Trough levels are most reproducible.

Causes for Rejection

Clotted specimen

Test Details


Monitor immunosuppressive therapy following organ transplant


This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

3.0−20.0 ng/mL

Additional Information

Sirolimus may be administered in conjunction with cyclosporine (CsA) and corticosteroids to reduce or prevent host graft rejection. Using this therapy, peak concentrations are achieved in one to two hours. The mean terminal elimination half-life is 62 hours.1 Drug-drug interactions, including CsA, may alter the pharmacokinetics of sirolimus, making therapeutic drug monitoring appropriate.


1. MacDonald A, Scarola J, Burke JT, et al. Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus. Clin Ther. 2000; 22(Suppl B):B101-121 (review). 10823378


Taylor PJ, Johnson AG. Quantitative analysis of sirolimus (Rapamycin®) in blood by high-performance liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 1998; 718(2):251-257. 9840435


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
716712 Sirolimus (Rapamune), Blood 29247-4 716724 Sirolimus, Blood ng/mL 29247-4

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at