Methylmalonic Acid, Urine

CPT: 83921
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Test Includes

Creatinine, urine; methylmalonic acid, urine


Expected Turnaround Time

4 - 9 days


Related Documents


Specimen Requirements


Specimen

Urine (random)


Volume

5 mL


Minimum Volume

0.6 mL


Container

Plastic urine container, no preservative


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

19 days

Freeze/thaw cycles

Stable x3


Test Details


Use

Diagnose cobalamin (vitamin B12) deficiency


Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)


Reference Interval

0.4−2.5 μmol/mmol crt


References

Matchar DB, Feussner JR, Millington DS, Wilkinson RH Jr, Watson DJ, Gale D. Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. Ann Intern Med. 1987 May; 106(5):707-710. 3551712
Specker BL, Miller D, Norman EJ, Greene H, Hayes KC. Increased urinary methylmalonic acid excretion in breast-fed infants of vegetarian mothers and identification of an acceptable dietary source of vitamin B12.Am J Clin Nutr. 1988 Jan, 47(1):89-92. 3337042
Stabler SP, Marcell PD, Podell ER, Allen RH, Lindenbaum J. Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry. J Clin Invest. 1986 May, 77(5):1606-1612.3700655

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
716365 Methylmalonic Acid, Urine 716348 Methylmalonic Acid, U umol/L 32287-5
716365 Methylmalonic Acid, Urine 716445 MMA - Normalized umol/mmol cr 25116-5
716365 Methylmalonic Acid, Urine 723281 Creatinine(Crt), U g/L 2161-8

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