716365: Methylmalonic Acid, Urine

Test Details

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Result Turnaround Time

4 - 9 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Test Includes

Creatinine, urine; methylmalonic acid, urine

Use

Diagnose cobalamin (vitamin B₁₂) deficiency

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Urine (random)

Volume

5 mL

Minimum Volume

0.6 mL

Container

Plastic urine container, no preservative

Stability Requirements

Temperature	Period
Room temperature	14 days
Refrigerated	14 days
Frozen	19 days
Freeze/thaw cycles	Stable x3

Reference Range

0.4−2.5 μmol/mmol crt

Storage Instructions

Room temperature

References

Matchar DB, Feussner JR, Millington DS, Wilkinson RH Jr, Watson DJ, Gale D. Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B₁₂ deficiency. A prospective clinical evaluation. Ann Intern Med. 1987 May; 106(5):707-710. 3551712

Specker BL, Miller D, Norman EJ, Greene H, Hayes KC. Increased urinary methylmalonic acid excretion in breast-fed infants of vegetarian mothers and identification of an acceptable dietary source of vitamin B_12.Am J Clin Nutr. 1988 Jan, 47(1):89-92. 3337042

Stabler SP, Marcell PD, Podell ER, Allen RH, Lindenbaum J. Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry. J Clin Invest. 1986 May, 77(5):1606-1612.3700655

LOINC® Map

Order Code	Order Code Name	Result Code	Result Code Name	UofM	Result LOINC
716365	Methylmalonic Acid, Urine	716348	Methylmalonic Acid, U	umol/L	32287-5
716365	Methylmalonic Acid, Urine	716445	MMA - Normalized	umol/mmol cr	25116-5
716365	Methylmalonic Acid, Urine	723281	Creatinine(Crt), U	g/L	2161-8
Order Code	716365
Order Code Name	Methylmalonic Acid, Urine
Order Loinc
Result Code	716348
Result Code Name	Methylmalonic Acid, U
UofM	umol/L
Result LOINC	32287-5
Order Code	716365
Order Code Name	Methylmalonic Acid, Urine
Order Loinc
Result Code	716445
Result Code Name	MMA - Normalized
UofM	umol/mmol cr
Result LOINC	25116-5
Order Code	716365
Order Code Name	Methylmalonic Acid, Urine
Order Loinc
Result Code	723281
Result Code Name	Creatinine(Crt), U
UofM	g/L
Result LOINC	2161-8

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