Methylmalonic Acid, Urine

CPT: 83921
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Test Includes

Creatinine, urine; methylmalonic acid, urine

Expected Turnaround Time

4 - 9 days

Related Documents

Specimen Requirements


Urine (random)


5 mL

Minimum Volume

0.6 mL


Plastic urine container, no preservative

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


19 days

Freeze/thaw cycles

Stable x3

Test Details


Diagnose cobalamin (vitamin B12) deficiency


This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

0.4−2.5 μmol/mmol crt


Matchar DB, Feussner JR, Millington DS, Wilkinson RH Jr, Watson DJ, Gale D. Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. Ann Intern Med. 1987 May; 106(5):707-710. 3551712
Specker BL, Miller D, Norman EJ, Greene H, Hayes KC. Increased urinary methylmalonic acid excretion in breast-fed infants of vegetarian mothers and identification of an acceptable dietary source of vitamin B12.Am J Clin Nutr. 1988 Jan, 47(1):89-92. 3337042
Stabler SP, Marcell PD, Podell ER, Allen RH, Lindenbaum J. Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry. J Clin Invest. 1986 May, 77(5):1606-1612.3700655


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
716365 Methylmalonic Acid, Urine 716348 Methylmalonic Acid, U umol/L 32287-5
716365 Methylmalonic Acid, Urine 716445 MMA - Normalized umol/mmol cr 25116-5
716365 Methylmalonic Acid, Urine 723281 Creatinine(Crt), U g/L 2161-8

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