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Human Immunodeficiency Virus 1 (HIV-1), Quantitative, Real-time PCR (Graphical) With Reflex to HIV-1 GenoSure PRIme® or GenoSure Archive®

CPT: 87536


  • HIV-1 Plasma Viremia
  • HiV-1 RNA Real-time PCR, Quantitative
  • Reflex to GenoSure Archive®
  • Reflex to GenoSure PRIme®
  • Viral Load

Special Instructions

If reflex test is performed, additional charges/CPT code(s) may apply.

Related Documents

Specimen Requirements


Plasma and whole blood


5 mL plasma and 4 mL EDTA whole blood

Minimum Volume

3.5 mL plasma and 3 mL EDTA whole blood


Lavender-top (EDTA) tube, screw-capped polypropylene frozen transport tube


Both frozen plasma and frozen whole blood are required for this profile. Draw three lavender-top (EDTA) tubes. Do not use green-top (heparin) tubes.

Plasma: Centrifuge two tubes within six hours of collection. Remove plasma, transfer plasma to screw-cap polypropylene transport tubes (not "pop-top" or "snap-cap"), and freeze. Ship specimen frozen.

Whole blood: Do not centrifuge. Freeze tube immediately after draw. Ship specimen frozen.

To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Stability Requirements

Frozen: 6 weeks

Causes for Rejection

Insufficient volume; heparinized plasma; specimen not frozen

Test Details


Detect and measure HIV-1 in plasma with reflex to GenoSure PRIme® if viral load is greater than or equal to 500 copies/mL or reflex to GenoSure Archive® if viral load is less than 500 copies/mL. The GenoSure PRIme® and GenoSure Archive® assays detect mutations in the HIV viral genes that encode for HIV protease, reverse transcriptase and integrase. Mutations in these genes have been associated with resistance to antiretroviral drugs.


This procedure should only be used for patients with a documented HIV-1 infection.


Cobas® AmpliPrep/Cobas® TaqMan® HIV-1 Test, Version 2.0 and polymerase chain reaction (PCR) amplification and DNA sequencing

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