Anti-Carbamylated Protein (CarP) Antibody

TEST: 520311
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CPT: 83516
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Synonyms

  • Anti-CarP antigen antibody
  • RA marker

Special Instructions

This test has not been approved for NY state clients.

Expected Turnaround Time

7 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Rheumatoid Arthritis: Novel Serologic Markers White Paper

Rheumatoid Arthritis Testing With Better Performance Brochure

Rheumatoid Arthritis (RA) Comprehensive Testing Brochure

    Specimen Requirements

    Specimen

    Serum

    Volume

    1 mL

    Minimum Volume

    0.5 mL

    Container

    Red-top tube; serum from red-top tube; serum from a gel tube; or serum gel tube

    Collection

    Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

    Storage Instructions

    Refrigerate or freeze.

    Stability Requirements

    Temperature

    Period

    Room temperature

    14 days

    Refrigerated

    14 days

    Frozen

    14 days

    Freeze/thaw cycles

    Stable x3

    Test Details

    Use

    Anti-CarP antibodies may be positive in about 10% of early RA patients who are RF-negative and anti-CCP-negative and may be present years before the onset of RA symptoms.1,2 Anti-CarP is associated with more active disease and higher risk of developing joint erosions.1 Anti-CarP levels especially in combination with RF- and Anti-CCP-positivity may predict joint erosion and radiographic progression.1

    Limitations

    This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

    Methodology

    Enzyme-linked immunosorbent assay (ELISA)

    Footnotes

    1. Truchetet ME, Dublanc S, Barnetche T, et al. Association of the Presence of Anti-Carbamylated Protein Antibodies in Early Arthritis With a Poorer Clinical and Radiologic Outcome: Data From the French ESPOIR Cohort. Arthritis Rheumatol. 2017 Dec;69(12):2292-2302.28853240
    2. Brink M, Verheul MK, Rönnelid J,et al. Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage. Arthritis Res Ther. 2015 Feb 7;17(1):25.25889922

    LOINC® Map

    Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
    520311 Anti-CarP Ab 66445-8 520312 Anti-CarP Ab Units 66445-8
    Reflex Table for Anti-CarP Ab
    Order Code Order Name Result Code Result Name UofM Result LOINC
    Reflex 1 000000

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