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Labcorp.com

Anti-Carbamylated Protein (CarP) Antibody

CPT: 83516
8351683516
8351683516
Updated on 09/14/2021
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Synonyms

  • Anti-CarP antigen antibody
  • RA marker

Special Instructions

This test has not been approved for NY state clients.


Related Documents

For more information, please view the literature below.

Rheumatoid Arthritis: Novel Serologic Markers White Paper

    For more information, please view the literature below.

    Rheumatoid Arthritis: Novel Serologic Markers White Paper


    Specimen Requirements


    Specimen

    Serum


    Volume

    1 mL


    Minimum Volume

    0.5 mL


    Container

    Red-top tube; serum from red-top tube; serum from a gel tube; or serum gel tube


    Collection

    Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.


    Storage Instructions

    Refrigerate or freeze.


    Stability Requirements

    Temperature

    Period

    Room temperature

    14 days

    Refrigerated

    14 days

    Frozen

    14 days

    Freeze/thaw cycles

    Stable x3


    Test Details


    Use

    Anti-CarP antibodies may be positive in about 10% of early RA patients who are RF-negative and anti-CCP-negative and may be present years before the onset of RA symptoms.1,2 Anti-CarP is associated with more active disease and higher risk of developing joint erosions.1 Anti-CarP levels especially in combination with RF- and Anti-CCP-positivity may predict joint erosion and radiographic progression.1


    Limitations

    This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


    Methodology

    Enzyme-linked immunosorbent assay (ELISA)


    Footnotes

    1. Truchetet ME, Dublanc S, Barnetche T, et al. Association of the Presence of Anti-Carbamylated Protein Antibodies in Early Arthritis With a Poorer Clinical and Radiologic Outcome: Data From the French ESPOIR Cohort. Arthritis Rheumatol. 2017 Dec;69(12):2292-2302.28853240
    2. Brink M, Verheul MK, Rönnelid J,et al. Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage. Arthritis Res Ther. 2015 Feb 7;17(1):25.25889922

    LOINC® Map

    Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
    520311 Anti-CarP Ab 520312 Anti-CarP Ab Units Pending

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