Our global life sciences company brings diagnostic testing & drug development together.
14-3-3 eta protein; Anti-CEP1 (citrullinated alpha-enolase 1) Ab; Anti-Sa (citrullinated vimentin) Ab; Anti-CarP (carbamylated protein) Ab
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
For more information, please view the literature below.
1.5 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Grossly hemolyzed; bacterial contamination; lipemic, icteric, non-serum specimen types
SeroNeg RAdx4 is a diagnostic and prognostic panel for Rheumatoid Arthritis designed to complement traditional RF and Anti-CCP testing.
This profile, consisting of 14-3-3 eta protein, Anti-CEP1 (citrullinated alphaenolase 1) Ab, Anti-Sa (citrullinated vimentin) Ab, and the novel Anti-CarP (carbamylated protein) Ab, enhances the diagnosis of established or early RA (especially in individuals seronegative for RF and Anti-CCP Ab) and may also help predict disease severity.
Decrease in 14-3-3 eta and/or Anti-Sa Ab with treatment is associated with less radiographic progression. The presence of Anti-CEP1 and Anti-CCP Antibodies suggests the imminent progression of pre-clinical RA into clinical RA. Anti-CarP may predict the development of RA independently of Anti-CCP and may be present years before the onset of symptoms in RA. Anti-CarP may confer a 10% incremental benefit in identify early RA and is associated with more active disease and higher risk of developing joint erosions.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Enzyme-linked immunosorbent assay (ELISA)
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|520305||SeroNeg RAdx4 Profile||520206||14.3.3 ETA, Rheum. Arthritis||ng/mL||75880-5|
|520305||SeroNeg RAdx4 Profile||520207||Anti-CEP-1 Ab, IgG (RDL)||Units||96561-6|
|520305||SeroNeg RAdx4 Profile||520208||Anti-Sa Ab, IgG (RDL)||Units||54022-9|
|520305||SeroNeg RAdx4 Profile||520317||Anti-CarP Ab||Units||Pending|
© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf