Anti-U1 RNP Ab (RDL)

CPT: 86235
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Synonyms

  • Anti-RNP

Expected Turnaround Time

5 - 7 days


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Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Refrigerate or freeze.


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1


Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types


Test Details


Use

Anti-U1 RNP antibodies typically appear in both SLE and MCTD. In MCTD, the presence of U1 RNP is required for diagnosis, whereas anti-RNP antibodies occur in only 30-40% of SLE. MCTD is typified by the high-titer RNP antibody activity in isolation; anti-RNP antibody activity in SLE commonly accompanies anti-Sm antibodies.


Methodology

Enzyme-linked immunosorbent assay (ELISA)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520034 Anti-U1 RNP Ab (RDL) 53022-0 520035 Anti-U1 RNP Ab (RDL) Units 53022-0

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