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This test is a component of Interstitial Lung Disease Panel I, Interstitial Lung Disease Panel II, ILdx Complete, MyoMarker 3 Plus Profile, MyoMarker 3 Profile.
7 - 14 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
0.5 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Refrigerate or freeze.
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
The presence of these antibodies, when considered in conjunction with other laboratory and clinical findings, is an aid in the diagnosis of systemic lupus erythematosus (SLE), Sjögren’s Syndrome (SS), systemic sclerosis (SSC), polymyositis (PM) and dermatomyositis (DM). SS-A/Ro antigen are found in 40-60% of patients withSjögren’s Syndrome and in 25-35% of patients with SLE. At one time it was thought that two different proteins, SS-A 52 and SS-A 60, were needed to account for SS-A antigenic reactivity. Now it is known that SS-A 52 and SS-A 60 proteins are not linked in the same particle. In addition, anti-SS-A 52 autoantibodies are distinct from, and have a different clinical utility than, anti-SS-A 60 antibodies. Just like anti-SS-A 60, anti-SS-A 52 is commonly found in patients with SLE and Sjgren's Syndrome, and occasionally in other autoimmune disorders. However, anti-SS-A 52 autoantibodies are also found in patients with systemic sclerosis, polymyositis and dermatomyositis. Anti-SSA 52 are linked with antibodies to tRNA synthetases like Jo-1, PL-7, PL-12, EJ and OJ, which are often found in patients with interstitial lung involvement. Studies show that 10-45% of myositis is positive with SSA52 antibody. An RDL study revealed 38% of myositis patients (18/47) were positive for SS-A 52 antibody. RDL offers SS-A 52 antibody test as part of the myositis panel.
Enzyme-linked immunosorbent assay (ELISA)
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