LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.

Anti-SS-A 52kD Ab, IgG (RDL)

CPT: 86235
Updated on 09/23/2020
Print Share


  • Topoisomerase 1

Test Includes

This test is a component of Interstitial Lung Disease Panel I, Interstitial Lung Disease Panel II, ILdx Complete, MyoMarker 3 Plus Profile, MyoMarker 3 Profile.

Expected Turnaround Time

14 - 21 days

7 - 14 days

14 - 21 days

Specimen Requirements




2 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Refrigerate or freeze.

Stability Requirements



Room temperature

7 days


14 days


60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Test Details


The presence of these antibodies, when considered in conjunction with other laboratory and clinical findings, is an aid in the diagnosis of systemic lupus erythematosus (SLE), Sjögren’s Syndrome (SS), systemic sclerosis (SSC), polymyositis (PM) and dermatomyositis (DM). SS-A/Ro antigen are found in 40-60% of patients withSjögren’s Syndrome and in 25-35% of patients with SLE. At one time it was thought that two different proteins, SS-A 52 and SS-A 60, were needed to account for SS-A antigenic reactivity. Now it is known that SS-A 52 and SS-A 60 proteins are not linked in the same particle. In addition, anti-SS-A 52 autoantibodies are distinct from, and have a different clinical utility than, anti-SS-A 60 antibodies. Just like anti-SS-A 60, anti-SS-A 52 is commonly found in patients with SLE and Sjgren's Syndrome, and occasionally in other autoimmune disorders. However, anti-SS-A 52 autoantibodies are also found in patients with systemic sclerosis, polymyositis and dermatomyositis. Anti-SSA 52 are linked with antibodies to tRNA synthetases like Jo-1, PL-7, PL-12, EJ and OJ, which are often found in patients with interstitial lung involvement. Studies show that 10-45% of myositis is positive with SSA52 antibody. An RDL study revealed 38% of myositis patients (18/47) were positive for SS-A 52 antibody. RDL offers SS-A 52 antibody test as part of the myositis panel.


Enzyme-linked immunosorbent assay (ELISA)


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520015 Anti-SS-A 52kD Ab, IgG (RDL) 56549-9 520039 Anti-SS-A 52kD Ab, IgG (RDL) Units 56549-9

For Providers

Please login to order a test

Order a Test

© 2020 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at