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Anti-Sm Ab (RDL)

CPT: 86235

Synonyms

  • Anti-Extractable Nuclear Antibodies
  • Anti-Smith Ab

Test Includes

This test is a component of Anti-ENA Abs, ANA Profile 11, ANA Profile 12, ANA 12 Plus Profile, ILDdx Complete.


Expected Turnaround Time

7 - 14 days


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Refrigerate or freeze.


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1


Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types


Test Details


Use

Anti-Sm antibodies offer a highly specific but relatively insensitive clinical marker of SLE. Their overall prevalence ranges from approximately 20-30% in SLE. Anti-Sm reactivity is not described definitively on other diseases, although a few studies describe Sm antibodies in monoclonal gammopathies and uveitis.


Methodology

Enzyme Immunoassay (EIA)


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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf