Anti-Ro, Total (Combined Anti-SS-A 52 kD and Anti-SS-A 60 kD Together)

Anti-Ro (SS-A) antibodies occur in 40-50% of SLE, 60-75% of primary Sjogren's syndrome (PSS) and in a high proportion of secondary SS whether the associated disease is in SLE, RA, PSS, polydermato-myositis, or primary biliary cirrhosis, but is >90% of subacute cutaneous lupus and in vasculitis-associated SS.

One numeric result for total anti-Ro is reported. Either anti-Ro52 and/or anti-Ro60 antibodies comprise this result. The presence of anti-Ro antibodies, when considered in conjunction with other laboratory and clinical findings, is an aid in the diagnosis of Sjögren’s Syndrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), idiopathic inflammatory myopathy (IIM), also known as polymyositis (PM) and dermatomyositis (DM), and overlap syndromes including mixed connective tissue disease (MCTD). Anti-Ro occur in 60% to 90% of primary SS, 30% to 50% of SLE, 10% to 15% SSc, 10% to 25% PM/DM, 10% to 20% of MCTD, 5% to 10% of rheumatoid arthritis and 10% to 15% of autoimmune hepatitis/primary biliary cholangitis. Autoantibodies to either part of the Ro (SS-A) antigen, the 52 kilodalton and/or 60 kilodalton, comprise anti-Ro, total.