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Anti-Mi-2 Ab (RDL)

CPT: 83516

Synonyms

  • Anti-Mi-2
  • Mi2

Expected Turnaround Time

7 - 14 days


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Refrigerate or freeze.


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1


Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types


Test Details


Use

Anti-Mi-2 antibodies are found in 10-20% of adult dermatomyositis (DM) and <10% of JDM. They are associated with classic DM features: mild to moderate weakness with shawl rash, heliotrope rash, V-sign, Gottron's papules, and have a good response to therapy, with lower incidence of cancer compared to Mi-2 negative DM.


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

RIPA Gel Radiography


Reference Interval

Negative


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