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Synonyms
- BAP
- Ostase®
- Skeletal Alkaline Phosphatase (SALP)
Expected Turnaround Time
2 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Gel-barrier tube or transport tube
Collection
Separate serum from cells within 45 minutes of collection. If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Gross hemolysis; quantity not sufficient for analysis
Test Details
Use
Quantitative measurement of skeletal alkaline phosphatase to be used as an aid in the management of patients with Paget disease and osteoporosis
Limitations
Serum specimens with significant elevations of liver alkaline phosphatase may cause aberrantly elevated results with the Ostase® assay.
Methodology
Immunochemiluminometric assay (ICMA)
Contraindications
Patients who have undergone therapy that includes infusion with mouse monoclonal antibody may produce erroneous results.
Reference Interval
Reference interval change (November 2015)1-3
Age | Male (μg/L) | Female (μg/L) |
|---|---|---|
0 to 5 m | Not established | Not established |
6 to 11 m | 48.2−170.2 | 50.4−154.0 |
1 y | 41.9−229.6 | 44.2−178.3 |
2 y | 41.7−139.4 | 34.9−195.4 |
3 to 4 y | 37.2−127.7 | 37.4−96.8 |
5 to 6 y | 42.0−104.2 | 31.4−100.8 |
7 to 8 y | 59.0−101.3 | 44.0−135.8 |
9 to 10 y | 50.4−133.0 | 47.9−150.8 |
11 to 12 y | 53.3−156.8 | 24.2−133.3 |
13 to 14 y | 77.5−169.8 | 19.8−92.7 |
15 to 16 y | 26.8−173.4 | 11.2−30.2 |
17 to 18 y | 15.4−69.8 | 8.8−29.0 |
19 to 20 y | 12.2−36.6 | 7.7−16.8 |
21 to 29 y | 7.4−27.7 | See below |
30 to 34 y | 7.0−27.4 | See below |
35 to 39 y | 4.0−27.0 | See below |
40 to 44 y | 7.4−26.7 | See below |
45 to 49 y | 7.5−26.4 | See below |
50 to 54 y | 7.5−26.1 | See below |
55 to 59 y | 7.5−25.7 | See below |
60 to 64 y | 7.5−25.4 | See below |
65 to 69 y | 7.6−25.1 | See below |
70 to 74 y | 7.6−24.8 | See below |
75 to 100 y | 7.6−24.4 | See below |
Female | ||
Premenopausal: 6.0−22.7 μg/L | ||
Postmenopausal: 8.1−31.6 μg/L | ||
Footnotes
1. Wyness SP, Roberts WL, Straseski JA. Pediatric reference intervals for four serum bone markers using two automated immunoassays. Clin Chim Acta. 2013 Jan 16; 415:169-172. 23122966
2. Cavalier E, Delanaye P. Analytical performance of a new bone-specific ALP automated immunoassay. J Am Soc Nephrol 24. 2013:754A.
3. Michelsen J, Wallaschofski H, Friedrich N, et al. Reference intervals for serum concentrations of three bone turnover markers for men and women. Bone. 2013 Dec; 57(2):399-404. 24076251
References
Delmas PD. Biochemical markers of bone turnover: Methodology and clinical use in osteoporosis. Am J Med. 1991; 91(5B):59S-63S. 1750421
van Straalen JP, Sanders E, Prummel MF, et al. Bone-alkaline phosphatase as indicator of bone formation. Clin Chim Acta. 1991; 201(1-2):27-33. 1790624
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 513002 | Alk Phosphatase, Bone Specific | 513004 | Tandem-R Ostase | ug/L | 17838-4 | |
| 513002 | Alk Phosphatase, Bone Specific | 511958 | 51969-4 |
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