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Myeloproliferative Neoplasms/Chronic Myelogenous Leukemia (MPN/CML), FISH

CPT: Contact CPT coding department at 800-222-7566, ext 6-8400.
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Synonyms

  • Leukemia/Lymphoma-specific FISH
  • Myeloproliferative Neoplasms

Test Includes

Fluorescence in situ hybridization (FISH) for myeloproliferative neoplasms/chronic myelogenous leukemia (MPN/CML) targeting numerical changes of chromosomes 8, 9, 13q14, and rearrangement of BCR/ABL1.


Special Instructions

Include the pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest with the test request form.


Expected Turnaround Time

3 - 5 days



Related Documents


Specimen Requirements


Specimen

Bone marrow, blood, cerebrospinal fluid (CSF), FNA, bone marrow touch prep slides


Volume

3 mL bone marrow (For additional cytogenetic studies an additional 1 mL of bone marrow is required.), fixed-cell pellet, three slides


Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, five slides, 2 mL blood, or 1 mL bone marrow (For additional cytogenetic studies, an additional 1 mL of bone marrow is required.)


Container

Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube


Storage Instructions

Maintain specimens at room temperature.


Causes for Rejection

Broken or dirty slides; excessive cellular debris; stains on slides


Test Details


Use

Confirmation/identification of chromosome abnormalities in interphase nuclei. Leukemia monitoring of residual disease.


Methodology

Fluorescence in situ hybridization (FISH)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511425 MPN/CML FISH 511087 Specimen Type 31208-2
511425 MPN/CML FISH 511088 Cells Counted 62361-1
511425 MPN/CML FISH 511091 Cells Analyzed 62360-3
511425 MPN/CML FISH 511092 FISH Result 62356-1
511425 MPN/CML FISH 511093 Interpretation 62365-2
511425 MPN/CML FISH 511094 Director Review: 48672-0
511425 MPN/CML FISH 512123 PDF 51967-8

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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf