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Myeloproliferative Neoplasms/Chronic Myelogenous Leukemia (MPN/CML), FISH

CPT Contact CPT coding department at 800-222-7566, ext 6-8400.
Synonyms
  • Leukemia/Lymphoma-specific FISH
  • Myeloproliferative Neoplasms

Test Details

Methodology

Fluorescence in situ hybridization (FISH)

Result Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Test Includes

Fluorescence in situ hybridization (FISH) for myeloproliferative neoplasms/chronic myelogenous leukemia (MPN/CML) targeting numerical changes of chromosomes 8, 9, 13q14, and rearrangement of BCR/ABL1.

Use

Confirmation/identification of chromosome abnormalities in interphase nuclei. Leukemia monitoring of residual disease.

Special Instructions

Include the pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest with the test request form.

Specimen Requirements

Specimen

Bone marrow, blood, cerebrospinal fluid (CSF), FNA, bone marrow touch prep slides

Volume

3 mL bone marrow (For additional cytogenetic studies an additional 1 mL of bone marrow is required.), fixed-cell pellet, three slides

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, five slides, 2 mL blood, or 1 mL bone marrow (For additional cytogenetic studies, an additional 1 mL of bone marrow is required.)

Container

Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Storage Instructions

Maintain specimens at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris; stains on slides

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511425 MPN/CML FISH 511087 Specimen Type 31208-2
511425 MPN/CML FISH 511088 Cells Counted 62361-1
511425 MPN/CML FISH 511091 Cells Analyzed 62360-3
511425 MPN/CML FISH 511092 FISH Result 62356-1
511425 MPN/CML FISH 511093 Interpretation 62365-2
511425 MPN/CML FISH 511094 Director Review: 48672-0
511425 MPN/CML FISH 512123 PDF 11502-2
Order Code511425
Order Code NameMPN/CML FISH
Order Loinc
Result Code511087
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code511425
Order Code NameMPN/CML FISH
Order Loinc
Result Code511088
Result Code NameCells Counted
UofM
Result LOINC62361-1
Order Code511425
Order Code NameMPN/CML FISH
Order Loinc
Result Code511091
Result Code NameCells Analyzed
UofM
Result LOINC62360-3
Order Code511425
Order Code NameMPN/CML FISH
Order Loinc
Result Code511092
Result Code NameFISH Result
UofM
Result LOINC62356-1
Order Code511425
Order Code NameMPN/CML FISH
Order Loinc
Result Code511093
Result Code NameInterpretation
UofM
Result LOINC62365-2
Order Code511425
Order Code NameMPN/CML FISH
Order Loinc
Result Code511094
Result Code NameDirector Review:
UofM
Result LOINC48672-0
Order Code511425
Order Code NameMPN/CML FISH
Order Loinc
Result Code512123
Result Code NamePDF
UofM
Result LOINC11502-2