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Myeloproliferative Neoplasms/Chronic Myelogenous Leukemia (MPN/CML), FISH

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  • Leukemia/Lymphoma-specific FISH
  • Myeloproliferative Neoplasms

Test Includes

Fluorescence in situ hybridization (FISH) for myeloproliferative neoplasms/chronic myelogenous leukemia (MPN/CML) targeting numerical changes of chromosomes 8, 9, 13q14, and rearrangement of BCR/ABL1.

Special Instructions

Include the pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest with the test request form.

Expected Turnaround Time

3 - 5 days

Related Documents

Specimen Requirements


Bone marrow, blood, cerebrospinal fluid (CSF), FNA, bone marrow touch prep slides


3 mL bone marrow (For additional cytogenetic studies an additional 1 mL of bone marrow is required.), fixed-cell pellet, three slides

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, five slides, 2 mL blood, or 1 mL bone marrow (For additional cytogenetic studies, an additional 1 mL of bone marrow is required.)


Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Storage Instructions

Maintain specimens at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris; stains on slides

Test Details


Confirmation/identification of chromosome abnormalities in interphase nuclei. Leukemia monitoring of residual disease.


Fluorescence in situ hybridization (FISH)


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511425 MPN/CML FISH 511087 Specimen Type 31208-2
511425 MPN/CML FISH 511088 Cells Counted 62361-1
511425 MPN/CML FISH 511091 Cells Analyzed 62360-3
511425 MPN/CML FISH 511092 FISH Result 62356-1
511425 MPN/CML FISH 511093 Interpretation 62365-2
511425 MPN/CML FISH 511094 Director Review: 48672-0
511425 MPN/CML FISH 512123 PDF 51967-8

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