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Fluorescence in situ hybridization (FISH) for myeloproliferative neoplasms/chronic myelogenous leukemia (MPN/CML) targeting numerical changes of chromosomes 8, 9, 13q14, and rearrangement of BCR/ABL1.
Include the pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest with the test request form.
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Bone marrow, blood, cerebrospinal fluid (CSF), FNA, bone marrow touch prep slides
3 mL bone marrow (For additional cytogenetic studies an additional 1 mL of bone marrow is required.), fixed-cell pellet, three slides
Fixed-cell pellet from a cytogenetic analysis, five slides, 2 mL blood, or 1 mL bone marrow (For additional cytogenetic studies, an additional 1 mL of bone marrow is required.)
Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube
Maintain specimens at room temperature.
Broken or dirty slides; excessive cellular debris; stains on slides
Confirmation/identification of chromosome abnormalities in interphase nuclei. Leukemia monitoring of residual disease.
Fluorescence in situ hybridization (FISH)
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|511425||MPN/CML FISH||511087||Specimen Type||31208-2|
|511425||MPN/CML FISH||511088||Cells Counted||62361-1|
|511425||MPN/CML FISH||511091||Cells Analyzed||62360-3|
|511425||MPN/CML FISH||511092||FISH Result||62356-1|
|511425||MPN/CML FISH||511094||Director Review:||48672-0|
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