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EWSR1 Oncology FISH

CPT: Contact CPT coding department at 800-222-7566, ext 6-8400.
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  • Angiomatoid Fibrous Histiocytoma Gene
  • Clear Cell Sarcoma Gene
  • Desmoplastic Small Round Cell Tumor Gene
  • Ewing Sarcoma Breakpoint Region 1
  • Leukemia FISH
  • Lymphoma FISH
  • Peripheral Neuroectodermal Tumor Gene

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.

Expected Turnaround Time

3 - 5 days

Specimen Requirements


Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.


Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow


Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube


Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen

Test Details


Confirmation/identification of cancer-related alterations (Ewing sarcoma)


Fluorescence in situ hybridization (FISH)

Additional Information

Ewing sarcoma EWSR1 rearrangement (usually fused with FLI1) is the primary alteration in PNETs and also in desmoplastic round cell tumors where it is fused with WT1. EWSR1 is also rearranged in clear cell and chondrosarcomas.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510379 EWSR1 Oncology FISH 510280 Specimen Type 31208-2
510379 EWSR1 Oncology FISH 510281 Cells Counted n/a
510379 EWSR1 Oncology FISH 510284 Cells Analyzed n/a
510379 EWSR1 Oncology FISH 510377 FISH Result 48674-6
510379 EWSR1 Oncology FISH 510286 Interpretation 50398-7
510379 EWSR1 Oncology FISH 510378 Director Review: 48672-0

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