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For hours, walk-ins and appointments.Test Includes
Fluorescence in situ hybridization (FISH) for aggressive B‐cell lymphoma, targeting rearrangement of BCL2, BCL6, and MYC
Special Instructions
Indicate the pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the laboratory.
Expected Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Blood, bone marrow, slides, paraffin block, lymph node, or touch preps
Volume
7 mL blood (adult), 1-3 mL bone marrow, five slides from cytogenetic analysis or seven slides from paraffin block, one tube fixed pellet, 4 touch prep slides
Minimum Volume
1 mL blood, 1 mL bone marrow, and four- to five-micron FFPE slides, 5 touch prep slides
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube
Storage Instructions
Maintain specimens at room temperature.
Causes for Rejection
Broken Vacutainer®; broken slides
Test Details
Use
Diagnostic test for non-Hodgkin’s lymphoma (NHL). Detects primary genetic changes associated with various types of NHL, including follicular lymphoma (FL), Burkitt's lymphoma (BL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), and those with BCL6 rearrangement.
Limitations
Molecular mutations below the resolution of FISH will not be detected.
Methodology
Fluorescence in situ hybridization (FISH)
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 510344 | Aggressive B Cell Lymphoma | 510623 | Cells Counted | 62361-1 | ||
| 510344 | Aggressive B Cell Lymphoma | 510624 | Cells Analyzed | 62360-3 | ||
| 510344 | Aggressive B Cell Lymphoma | 510625 | FISH Result | 48674-6 | ||
| 510344 | Aggressive B Cell Lymphoma | 510341 | Interpretation | 50398-7 | ||
| 510344 | Aggressive B Cell Lymphoma | 510627 | Specimen Type | 31208-2 | ||
| 510344 | Aggressive B Cell Lymphoma | 510342 | Director Review: | 48672-0 |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf