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Fluorescence in situ hybridization (FISH) for acute lymphoblastic leukemia (ALL), targeting rearrangement of BCR-ABL, TCF3, KMT2A (MLL), ETV6/RUNX1, and numerical changes of 4, 10, 17, and CDKN2A deletion.
Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form.
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei or bone marrow touch preparation slides are acceptable for testing.
5 mL blood (pediatric), 3 mL bone marrow, fiexed-cell pellet from a cytogenetic analysis, 12 slides with metaphase and/or interphase nuclei or 12 touch preparation slides.
1 mL blood (pediatric), 1 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 6 slides with metaphase and/or interphase nuclei or 6 touch preparation slides. (Note: Minimum volumes may not allow for repeat testing.)
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). Adjust tube size to sample volume to avoid heparin toxicity.
Transport to the testing laboratory at room temperature, use of a cool pack or a LabCorp transport kit is acceptable. Do not allow samples to overheat or freeze.
Maintain the specimen at either room temperature or refrigerate. Do not freeze.
Broken Vacutainer®; broken or stained slides; paraffin blocks; paraffin slides; decalcified bone cores; frozen specimen; quantity not sufficient for analysis
Diagnostic and prognostic test for acute lymphoblastic leukemia in the pediatric population; detection rate is improved from 50% with a chromosome study to 90% with FISH
Molecular mutations or chromosomal alterations not targeted by the probes included in this profile will not be detected.
Fluorescence in situ hybridization (FISH)
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|510324||FISH Pediatric ALL Oncology||510709||Specimen Type||31208-2|
|510324||FISH Pediatric ALL Oncology||510687||Cells Counted||62361-1|
|510324||FISH Pediatric ALL Oncology||510688||Cells Analyzed||62360-3|
|510324||FISH Pediatric ALL Oncology||510689||FISH Result||48674-6|
|510324||FISH Pediatric ALL Oncology||510326||Interpretation||50398-7|
|510324||FISH Pediatric ALL Oncology||510327||Director Review:||48672-0|
|510324||FISH Pediatric ALL Oncology||512123||51967-8|
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