Labcorp
Our global life sciences company brings diagnostic testing & drug development together.
Alert:
Labcorp has multiple COVID-19 testing options. Learn more >>>
Voltage-Gated Potassium Channel (VGKC) Complex Antibodies: Anti LGI1 and Anti CASPR2, with Reflex to Titer, Serum
CPT:
86255(x2)
Special Instructions
If reflex test is performed, additional charges/CPT code(s) may apply.
Expected Turnaround Time
3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Gel-barrier tube, red-top tube, serum gel tube, serum transfer tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
CSF or plasma; contaminated, hemolyzed or severely lipemic specimens
Test Details
Use
Voltage-Gated Potassium Channel (VGKC) antibodies (predominately Anti-LGI1 and Anti-CASPR2) are associated with paraneoplastic neurological syndromes and limbic encephalitis. These antibodies may also be found in other conditions such as acquired neurmyotonia, painful neuropathy, Morvan's syndrome, and rare tumors (eg, thymoma, small-cell lung cancer).
This indirect fluorescent antibody assay utilizes LGI1 and CASPR2 transfected cell lines for the detection and semi-quantification of autoantibodies.
Limitations
Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established product or procedure.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Immunofluorescence (IFA)
References
van Sonderen A, Schreurs MW, Wirtz PW, Sillevis Smitt PA, Titulaer MJ. From VGKC to LG1 and Caspr2 encephalitis: The evolution of a disease entity over time. Autoimmun Rev. 2016 Oct;15(10):970-974.27485013
van Sonderen A, Petit-Pedrol M, Dalmu J, Titulaer MJ. The value of LGI1, CASPR2 and voltage-gated potassium channel antibodies in encephalitis. Nat Rev Neurol. 2017 May;13(5):290-301.28418022
Willis MD, Jones L, Vincent A, Wheeler R, O'Callaghan P, Hamandi K. VGKC-complex antibody encephalitis. QJM. 2014 Aug;107(8):657-659.24517999
Zuliani L, Nosadini M, Gastaldi M, et al. Management of antibody-mediated autoimmune encephalitis in adults and children: literature review and consensus-based practical recommendations. Neurol Sci. 2019 Oct;40(10):2017-2030.31161339
© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.
CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf