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Anti-Hu, Ri, Yo Antibody Profile, Serum

CPT: 86255(x3)
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Special Instructions

If reflex test is performed, additional charges/CPT code(s) may apply.


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Specimen Requirements


Specimen

Serum


Volume

2 mL


Minimum Volume

1 mL (Note: This volume does not allow for repeat testing.)


Container

Serum from a red-top tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Gross hemolysis; grossly lipemic


Test Details


Use

Evaluation of patients with suspected paraneoplastic neurologic syndrome such as encephalomyelitis.


Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Immunofluorescence (IFA)


Additional Information

Antibodies to Hu, Ri and Yo antigens are present in patients with paraneoplastic neurologic syndrome such as encephalomyelitis. Hu antibodies are frequently associated with small cell lung cancer and neuroblastoma. Hu antibodies are rarely associated with non-small cell lung cancer, prostate cancer or seminoma. The paraneoplastic syndrome associated with the presence of antibodies to Ri includes symptoms such as opsocionus, ataxia, nystagmus, dizziness and dysarthria. Antibodies to Yo are associated with cerebellar degeneration as well as with small lung cancer, gynecologic and breast cancer.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
505240 Anti-Hu, Anti-Ri, Anti-Yo IFA 505241 Anti-Hu Ab pending
505240 Anti-Hu, Anti-Ri, Anti-Yo IFA 505243 Anti-Ri Ab pending
505240 Anti-Hu, Anti-Ri, Anti-Yo IFA 505245 Anti-Yo Ab pending
Reflex Table for Anti-Hu Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505242 Anti-Hu Ab Line Blot 505242 Anti-Hu Ab Line Blot pending
Reflex Table for Anti-Ri Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505244 Anti-Ri Ab Line Blot 505244 Anti-Ri Ab Line Blot pending
Reflex Table for Anti-Yo Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505246 Anti-Yo Ab Line Blot 505246 Anti-Yo Ab Line Blot pending

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf