Find Locations
For hours, walk-ins and appointments.Special Instructions
If reflex test is performed, additional charges/CPT code(s) may apply.
Expected Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL (Note: This volume does not allow for repeat testing.)
Container
Serum from a red-top tube, gel-barrier tube, or serum transfer tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Gross hemolysis; grossly lipemic
Test Details
Use
Evaluation of patients with suspected paraneoplastic neurologic syndrome such as encephalomyelitis.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Immunofluorescence (IFA)
Additional Information
Antibodies to Hu, Ri and Yo antigens are present in patients with paraneoplastic neurologic syndrome such as encephalomyelitis. Hu antibodies are frequently associated with small cell lung cancer and neuroblastoma. Hu antibodies are rarely associated with non-small cell lung cancer, prostate cancer or seminoma. The paraneoplastic syndrome associated with the presence of antibodies to Ri includes symptoms such as opsocionus, ataxia, nystagmus, dizziness and dysarthria. Antibodies to Yo are associated with cerebellar degeneration as well as with small lung cancer, gynecologic and breast cancer.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 505240 | Anti-Hu, Anti-Ri, Anti-Yo IFA | 505241 | Anti-Hu Ab | 49738-8 | ||
| 505240 | Anti-Hu, Anti-Ri, Anti-Yo IFA | 505243 | Anti-Ri Ab | 43187-4 | ||
| 505240 | Anti-Hu, Anti-Ri, Anti-Yo IFA | 505245 | PCA Type-1 (Anti-Yo) Ab | 84924-0 |
| Reflex Table for Anti-Hu Ab | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 505242 | Anti-Hu Ab Line Blot | 505242 | Anti-Hu Ab Line Blot | 94389-4 | |
| Reflex Table for Anti-Ri Ab | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 505244 | Anti-Ri Ab Line Blot | 505244 | Anti-Ri Ab Line Blot | 94387-8 | |
| Reflex Table for PCA Type-1 (Anti-Yo) Ab | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 505246 | Anti-Yo Ab Line Blot | 505246 | Anti-Yo Ab Line Blot | 94271-4 | |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf