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Thyroglobulin, Comprehensive (With Anti-Tg Screen and Reflex to RIA) (Endocrine Sciences)

CPT: 84432; 86800
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  • Extended-storage Comprehensive Thyroglobulin (With Anti-Tg Screen and Reflex to RIA)

Expected Turnaround Time

4 - 10 days

Specimen Requirements




5 mL

Minimum Volume

1.5 mL (Note: This volume does not allow for repeat testing.)


Gel-barrier tube or red-top tube


Transfer specimen to a plastic transport tube before freezing. Serum must be separated from cells within one hour of venipuncture. Submit serum in a plastic transport tube.

Storage Instructions

Freeze. Stable at room temperature for three days or refrigerated for 14 days. Stable when frozen for 3.79 years. Freeze/thaw cycles: stable x2.

Causes for Rejection

Plasma specimen received; gross hemolysis

Test Details


Comprehensive thyroglobulin can be used to monitor recurrence of thyroid cancer. All specimens are tested for the presence of antithyroglobulin autoantibodies (anti-Tg). Specimens negative for the presence of anti-Tg are reflexed to thyroglobulin testing by ICMA, and specimens positive for the presence of anti-Tg are reflexed to thyroglobulin testing by RIA.

Specimens submitted for comprehensive thyroglobulin testing are stored frozen for one year to allow for future testing.


Immunochemiluminometric (ICMA) or double antibody radioimmunoassay (RIA) when anti-Tg autoantibodies are present


Cooper DS, Doherty GM, Haugen BR, The American Thyroid Association Guideline Taskforce, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2006; 16(2):109-142. 16420177
Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 2003; 88(4):1433-1441. 12679418
National Academy for Clinical Biochemistry. Laboratory Support for the Diagnosis of Thyroid Disease. Vol 13. 2002:48-49.
Spencer CA, Bergoglio LM, Kazarosyan M, et al. Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas. J Clin Endocrinol Metab. 2005; 90(10):5566-5575. 15985472


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
500540 Comprehensive Thyroglobulin 500556 Anti-Thyroglobulin Antibodies IU/mL 8098-6
500540 Comprehensive Thyroglobulin 503191 Thyroglobulin (ICMA) ng/mL 3013-0
500540 Comprehensive Thyroglobulin 500002 Thyroglobulin (TG-RIA) ng/mL 3013-0

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