Test Details
Methodology
Electrochemiluminescence (ECL)
Result Turnaround Time
4 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Specimen Requirements
Specimen
Serum, frozen
Volume
1 mL
Minimum Volume
0.2 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection Instructions
Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Stability Requirements
| Temperature | Period |
|---|---|
| Room temperature | 1 day |
| Refrigerated | 14 days |
| Frozen | 14 days |
| Freeze/thaw cycles | Stable x6 |
Reference Range
See table.
| Age | Range (ng/mL) | Median (ng/mL) |
|---|---|---|
| Male | ||
| Birth to 6 y | 32.77−262.69 | 124.58 |
| 7 to 10 y | 45.26−191.34 | 92.52 |
| 20 to 98 y | 0.11−13.07 | 4.95 |
| Female | ||
| 0 to 6 y | 0.53−7.78 | 2.85 |
| 7 to 19 y | 1.05−12.86 | 5.23 |
| 20 to 25 y | 1.23−11.51 | 4.70 |
| 26 to 30 y | 1.03−11.10 | 4.20 |
| 31 to 35 y | 0.66−8.75 | 3.00 |
| 36 to 40 y | 0.42−8.34 | 1.69 |
| 41 to 46 y | 0.26−5.81 | 0.58 |
| 47 to 54 y | ≤0.82 | <0.03 |
| 55 to 97 y | ≤0.18 | <0.03 |
Storage Instructions
Freeze.
Causes for Rejection
Gross hemolysis; gross lipemia; specimen at room temperature
References
American College of Obstetricians and Gynecologists. Committee on Gynecologic Practice. Committee Opinion N° 618: Ovarian reserve testing. Obstet Gynecol. 2015 Jan; 125(1):268-273. 25560143
Broer SL, Broekmans FJ, Laven JS, Fauser BC. Anti-Müllerian hormone: Ovarian reserve testing and its potential clinical implications. Hum Reprod Update. 2014 Sep-Oct; 20(5):688-701. 24821925
Fleming R, Broekmans F, Calhaz-Jorge C, et. al. Can anti-Müllerian hormone concentrations be used to determine gonadotrophin dose and treatment protocol for ovarian stimulation? Reprod Biomed Online. 2013 May; 26(5):431-439. 23507133
Gleicher N, Weghofer A, Barad DH. Anti-Müllerian hormone (AMH) defines, independent of age, low versus good live-birth chances in women with severely diminished ovarian reserve. Fertil Steril. 2010 Dec; 94(7): 2824-2827. 20538269
Karkanaki A, Vosnakis C, Panidis D. The clinical significance of anti-Mullerian hormone evaluation in gynecological endocrinology. Hormones (Athens). 2011 Apr-Jun; 10(2): 95-103. 21724534
La Marca A, Broekmans FJ, Volpe A, Fauser BC, Macklon NS; ESHRE Special Interest Group for Reproductive Endocrinology—AMH Round Table. Anti-Müllerian hormone (AMH): What do we still need to know? Hum Reprod. 2009 Sep; 24(9):2264-2275. 19520713
La Marca A, Sighinolfi G, Radi D, et al. Anti-Müllerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update. 2010 Mar-Apr; 16(2):113-130. 19793843
Ledger WL. Clinical utility of measurement of anti-Müllerian hormone in reproductive endocrinology. J Clin Endocrinol Metab. 2010 Dec; 95(12):5144-5154. 21131535
van Disseldorp J, Faddy MJ, Themmen APN, et al. Relationship of serum antimüllerian hormone concentration to age at menopause. J Clin Endocrinol Metab. 2008 Jun; 93(6):2129-2134. 18334591
van Rooij IA, Broekmans FJ, Scheffer GJ, et al. Serum antimüllerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: A longitudinal study. Fertil Steril. 2005; 83(4):979-987. 15820810
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 500183 | Anti-Mullerian Hormone (AMH) | 38476-8 | 500184 | Anti-Mullerian Hormone (AMH) | ng/mL | 38476-8 |
| Order Code | 500183 | |||||
| Order Code Name | Anti-Mullerian Hormone (AMH) | |||||
| Order Loinc | 38476-8 | |||||
| Result Code | 500184 | |||||
| Result Code Name | Anti-Mullerian Hormone (AMH) | |||||
| UofM | ng/mL | |||||
| Result LOINC | 38476-8 |