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Anti-Müllerian Hormone (AMH) (Endocrine Sciences)

CPT: 82397
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Synonyms

  • Müllerian-inhibiting Substance

Expected Turnaround Time

4 - 10 days


Related Documents

For more information, please view the literature below.

Anti-Müllerian Hormone Assay


Specimen Requirements


Specimen

Serum, frozen


Volume

1 mL


Minimum Volume

0.2 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Freeze.


Stability Requirements

Temperature

Period

Room temperature

1 day

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x6


Causes for Rejection

Gross hemolysis; gross lipemia; specimen at room temperature


Test Details


Methodology

Electrochemiluminescence (ECL)


Reference Interval

See table.

Age

Range (ng/mL)

Median (ng/mL)

Male

Birth to 6 y

32.77−262.69

124.58

7 to 10 y

45.26−191.34

92.52

20 to 98 y

0.11−13.07

4.95

Female

0 to 6 y

0.53−7.78

2.85

7 to 19 y

1.05−12.86

5.23

20 to 25 y

1.23−11.51

4.70

26 to 30 y

1.03−11.10

4.20

31 to 35 y

0.66−8.75

3.00

36 to 40 y

0.42−8.34

1.69

41 to 46 y

0.26−5.81

0.58

47 to 54 y

≤0.82

<0.03

55 to 97 y

≤0.18

<0.03


References

American College of Obstetricians and Gynecologists. Committee on Gynecologic Practice. Committee Opinion N° 618: Ovarian reserve testing. Obstet Gynecol. 2015 Jan; 125(1):268-273. 25560143
Broer SL, Broekmans FJ, Laven JS, Fauser BC. Anti-Müllerian hormone: Ovarian reserve testing and its potential clinical implications. Hum Reprod Update. 2014 Sep-Oct; 20(5):688-701. 24821925
Fleming R, Broekmans F, Calhaz-Jorge C, et. al. Can anti-Müllerian hormone concentrations be used to determine gonadotrophin dose and treatment protocol for ovarian stimulation? Reprod Biomed Online. 2013 May; 26(5):431-439. 23507133
Gleicher N, Weghofer A, Barad DH. Anti-Müllerian hormone (AMH) defines, independent of age, low versus good live-birth chances in women with severely diminished ovarian reserve. Fertil Steril. 2010 Dec; 94(7): 2824-2827. 20538269
Karkanaki A, Vosnakis C, Panidis D. The clinical significance of anti-Mullerian hormone evaluation in gynecological endocrinology. Hormones (Athens). 2011 Apr-Jun; 10(2): 95-103. 21724534
La Marca A, Broekmans FJ, Volpe A, Fauser BC, Macklon NS; ESHRE Special Interest Group for Reproductive Endocrinology—AMH Round Table. Anti-Müllerian hormone (AMH): What do we still need to know? Hum Reprod. 2009 Sep; 24(9):2264-2275. 19520713
La Marca A, Sighinolfi G, Radi D, et al. Anti-Müllerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update. 2010 Mar-Apr; 16(2):113-130. 19793843
Ledger WL. Clinical utility of measurement of anti-Müllerian hormone in reproductive endocrinology. J Clin Endocrinol Metab. 2010 Dec; 95(12):5144-5154. 21131535
van Disseldorp J, Faddy MJ, Themmen APN, et al. Relationship of serum antimüllerian hormone concentration to age at menopause. J Clin Endocrinol Metab. 2008 Jun; 93(6):2129-2134. 18334591
van Rooij IA, Broekmans FJ, Scheffer GJ, et al. Serum antimüllerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: A longitudinal study. Fertil Steril. 2005; 83(4):979-987. 15820810

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
500183 Anti-Mullerian Hormone (AMH) 500184 Anti-Mullerian Hormone (AMH) ng/mL 38476-8

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