IgG Index and Synthesis Rate

CPT: 82040; 82042; 82784(x2)
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Expected Turnaround Time

3 - 5 days

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Specimen Requirements


Serum and cerebrospinal fluid (CSF)


1.5 mL serum and 1 mL CSF

Minimum Volume

0.7 mL serum and 0.5 mL CSF


Red-top tube or gel-barrier tube and sterile container for CSF

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


6 months

Freeze/thaw cycles

Stable x2

Test Details


Conditions in which lymphoreticular elements of the CNS produce immunoglobulins will result in false-positive (in relation to multiple sclerosis) elevations. Such conditions include (but are not limited to) aseptic meningitis, lymphoma, neurosyphilis, Guillain-Barré syndrome, and cerebral lupus erythematosus. These conditions, however, are either uncommon or are not frequently associated with an increased IgG index.


CSF IgG, CSF albumin and serum IgG: Immunologic; serum albumin: spectrophotometry; ratio, index and synthesis rate by calculation


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
203836 IgG Index+Synthesis Rate 012212 IgG, Quant, CSF mg/dL 2464-6
203836 IgG Index+Synthesis Rate 012230 Albumin, CSF mg/dL 1746-7
203836 IgG Index+Synthesis Rate 001776 Immunoglobulin G, Qn, Serum mg/dL 2465-3
203836 IgG Index+Synthesis Rate 001081 Albumin g/dL 1751-7
203836 IgG Index+Synthesis Rate 160311 IgG/Alb Ratio, CSF 2470-3
203836 IgG Index+Synthesis Rate 101124 CSF IgG Index 14117-6
203836 IgG Index+Synthesis Rate 085937 IgG, Syn Rate,CSF mg/day 14116-8
203836 IgG Index+Synthesis Rate 120173 CSF/Serum Alb. Index 1756-6

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