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Legionella pneumophila Urinary Antigen

CPT: 87449
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Expected Turnaround Time

1 - 3 days

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Specimen Requirements




5 mL


Sterile screw-cap container

Storage Instructions


Causes for Rejection

Swab specimen; inappropriate specimen transport device; unlabeled specimen or name discrepancy between specimen and request label; nonurine specimen

Test Details


Confirm the diagnosis of Legionella pneumophila serogroup 1 infection


This test will not detect species or serogroups other than Legionella pneumophila serogroup 1.


Enzyme immunoassay (EIA)

Reference Interval

No Legionella pneumophila serogroup 1 antigen detected

Additional Information

Legionella pneumophila has been estimated to cause 80% to 85% of Legionella infections, with serogroup 1 accounting for most of these. Current methods of diagnosis for Legionella infection include culture and DFA. All of these other tests require a high quality respiratory specimen to perform this test and, unfortunately, many patients with Legionella infection do not produce sputum. A number of investigators have shown that a specific soluble antigen was present in the urine of patients with Legionnaires' disease, which can be detected both early and late in the disease.


Berdal PP, Farshy CE, Feelley JC. Detection of Legionella pneumophila antigen in urine by enzyme-linked immunospecific assay. J Clin Microbiol. 1979 May; 9(5):575-578. 383744
Kohler RB, Zimmerman SE, Wilson E, et al. Rapid immunoassay diagnosis of Legionnaires' disease: Detection and partial characterization of urinary antigen. Ann Intern Med. 1981 May; 94(5):601-605. 7235392
Reingold AL, Thomason BM, Brake BJ, Thacker L, Wilkinson HW, Kuritsky JN. Legionella pneumonia in the United States: The distribution of serogroups and species causing human illness. J Infect Dis. 1984 May; 149(5):819. 6726009


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
182246 L. pneumophila Serogp 1 Ur Ag 41499-5 182246 L. pneumophila Serogp 1 Ur Ag 41499-5

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