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Killer Immunoglobulin-like Receptors (KIR)

CPT: 81403

Synonyms

  • KIR
  • KIR Genotyping
  • KIR SSO Genotyping Test
  • KIR Typing

Special Instructions

If you have questions or for assistance in selecting the proper KIR test for the patient, please call HLA customer serivce at 800-533-1037 or email [email protected]


Expected Turnaround Time

3 - 9 days


Specimen Requirements


Specimen

Whole blood


Volume

7 mL


Minimum Volume

3 mL


Container

Lavender-top (EDTA) tube


Storage Instructions

Maintain specimen at room temperature.


Causes for Rejection

Highly lipemic or hemolyzed specimen


Test Details


Use

The function of natural killer cells in the immune response is regulated by killer immunoglobulin-like receptors (KIR). These receptors interact with class I HLA antigens on the cell surface to prevent or activate killing of the target cell. KIR genotyping may be useful in some stem cell transplants because KIR matching or mismatching can mediate a graft-versus-leukemia effect when the cancer cells are underexpressing HLA class I antigens.


Limitations

Results for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.


Methodology

A panel of sequence-specific oligonucleotide probes (SSOP) on fluorescently labeled microspheres (beads) with probes that target specific alleles


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